The Toxicant Induction of Irritant Asthma, Rhinitis, and Related Conditions

  • William J. Meggs

Table of contents

  1. Front Matter
    Pages i-vi
  2. Michael R. Van Scott, Joyce Chandler, Stephen Olmstead, Jared M. Brown, Mark Mannie
    Pages 19-61
  3. Susan Ney Miller
    Pages 83-101
  4. Christopher J. Wingard, Emily Cozzi, Michael R. Van Scott, Robert M. Lust
    Pages 103-130
  5. Rebecca Bascom, Anne E. F. Dimmock, Judie Ann Howrylak
    Pages 131-192
  6. Payton A. Kuhlenbeck, Tanner J. Parrent
    Pages 193-205
  7. Grace Ziem
    Pages 207-217
  8. Ricky Langley, David Lipton
    Pages 219-230
  9. William J. Meggs
    Pages 277-286
  10. Back Matter
    Pages 287-294

About this book


Untoward reactions to environmental chemicals, particularly when a subject reports difficulties with exposures to chemicals of diverse classes involving more than one organ system, have been poorly understood and an area of great controversy. Studies of airway inflammation induced by respiratory irritants have established neurogenic inflammation as the mechanism for irritant asthma and rhinitis. Remodeling of the airway after an acute irritant exposure can lead to a heightened sensitivity to irritants that persists. Recognition that rhinitis, while sometimes regarded as a trivial disease, is associated with extra-airway manifestations such as fatigue and disturbances of sleep, mood, and cognition, further elucidates how chemical exposures can be serious for susceptible individuals.

This book reviews current scientific understanding of irritant airway inflammation and related conditions, including cardiovascular effects of particulate exposures, airborne contact dermatitis and irritant dermatitis, and the brain as a target organ for both allergic and irritant reactions. It is essential reading for physicians and other healthcare workers caring for patients with environmental intolerances.  Allergists, toxicologists, occupational and environmental physicians, and pulmonologists will find the materials particularly valuable. Patients and advocates for those with chemical intolerances will also find the book of interest.

Editors and affiliations

  • William J. Meggs
    • 1
  1. 1.East Carolina UniversityGreenvilleUSA

Bibliographic information

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