Materials, Methodologies, and Assessments

  • Nelson Durán
  • Silvia S. Guterres
  • Oswaldo L. Alves

Part of the Nanomedicine and Nanotoxicology book series (NANOMED)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Oswaldo L. Alves, Ana Carolina Mazarin de Moraes, Mateus Batista Simões, Leandro Carneiro Fonseca, Rafaella Oliveira do Nascimento, Raphael Dias Holtz et al.
    Pages 1-29
  3. Alexandre L. R. de Oliveira, Helder J. Ceragioli, Kyl Assaf
    Pages 31-55
  4. Ana Cauerhff, Yanina N. Martinez, German A. Islan, Guillermo R. Castro
    Pages 57-95
  5. Patricia S. Melo, Priscyla D. Marcato, Daniele R. de Araújo, Nelson Durán
    Pages 111-123
  6. Diego Stéfani T. Martinez, Leonardo P. Franchi, Camila M. Freria, Odair P. Ferreira, Antonio G. Souza Filho, Oswaldo L. Alves et al.
    Pages 125-152
  7. Giselle Z. Justo, Eloah R. Suarez, Carina Melo, Marcelo A. Lima, Helena B. Nader, Maria Aparecida S. Pinhal
    Pages 153-175
  8. Renata de Lima, Leonardo Fernandes Fraceto
    Pages 177-199
  9. Priscyla D. Marcato, Nelson Durán
    Pages 229-244
  10. Nelson Durán, Amedea B. Seabra, Renata de Lima
    Pages 245-263
  11. Amedea B. Seabra, Paula S. Haddad
    Pages 265-279
  12. Daniele R. de Araújo, Alisson Oshiro, Deyse Cardoso da Silva, Alessandra Cristina Santos Akkari, Joyce Cristine de Mello, Tiago Rodrigues
    Pages 281-298
  13. Solange C. Garcia, Silvia S. Guterres, Guilherme B. Bubols, Rachel P. Bulcão, Mariele F. Charão, Adriana R. Pohlmann
    Pages 299-324
  14. Mahendra Rai, Avinash Ingle, Indarchand Gupta, Swapnil Gaikwad, Aniket Gade, Olga Rubilar et al.
    Pages 325-345
  15. Luis A. Visani de Luna, Diego Stéfani T. Martinez, Oswaldo L. Alves
    Pages 347-361
  16. Andreia Fonseca de Faria, Ana Carolina Mazarin de Moraes, Oswaldo L. Alves
    Pages 363-405
  17. Back Matter
    Pages 407-411

About this book


This book takes a systematic approach to nanotoxicology and the developing risk factors associated with  nanosized particles during manufacture and use of nanotechnology. Beginning with a detailed introduction to engineered nanostructures, the first part of the book presents concepts and definitions of nanomaterials from quantum dots to graphene to fullerenes, with detailed discussion of functionalization, stability, and medical and biological applications. The second part critically examines methodologies used to assess cytotoxicity and genotoxicity. Coverage includes interactions with blood (erythrocytes), combinatorial and microarray techniques, cellular mechanisms, and ecotoxicology assessments. Part three describes cases studies both in vitro and in vivo for specific nanomaterials including solid lipid nanoparticles and nanostructured lipid carriers and metallic nanoparticles and metallic oxides. New information is also presented on toxicological aspects of poloxamers and polymeric nanoparticles as drug carriers as well as size effects on cytotoxicity and genotoxicity. Didactic aspects are emphasized in all chapters, making the book suitable for a broad audience ranging from advanced undergraduate and graduate students to researchers in academia and industry. In all, Nanotoxicology: Materials, Methodologies, and Assessments will provide comprehensive insight into biological and environmental interactions with nanostructures.

  • Provides an introduction to nanostructures actually in use
  • Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays
  • Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity
  • Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology


Biogenically Synthecized Silver Nanoparticles Carbon Nanostructures and Cellular Systems Interaction Cytotoxicity Cytotoxicity Methodologies Cytotoxicity and Genotoxicity Econanotoxicology Ecotoxicity Nanoparticles Fish and Crustaceans Erythrocyte Toxicity Nanomaterials Genetic Studies Nanomaterial Effects Genotoxicity Genotoxicity Methodologies Interaction Iron Oxide Nanoparticles Cytotoxicity and Genotoxicity Nanoparticle Cytotoxicity Nanostability Nanostructure Internalization Cellular Mechanism Nanotoxicology Nanotoxicology Methodologies Poloxamer Drug-delivery Systems Polymeric Nanoparticles Solid Lipid Nanoparticles Cytotoxicity and Genotoxicity Targeted Nanomedicines Development and Toxicological Profiling

Editors and affiliations

  • Nelson Durán
    • 1
  • Silvia S. Guterres
    • 2
  • Oswaldo L. Alves
    • 3
  1. 1.Institute of ChemistryUniversidade Estadual de Campinas—UNICAMPCampinasBrazil
  2. 2.Faculdade de FarmáciaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  3. 3.Institute of ChemistryUniversidade Estadual de Campinas—UNICAMPCampinasBrazil

Bibliographic information

Industry Sectors
Health & Hospitals
Pharmacology & Toxicology
Consumer Packaged Goods