Heterogeneity in Asthma

  • Allan R. Brasier

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 795)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The Spectrum of Asthma: An Introduction

    1. Front Matter
      Pages 1-4
    2. Regina A. Pillai, William J. Calhoun
      Pages 5-15
    3. Rohit Divekar, William J. Calhoun
      Pages 31-41
    4. Kristin Sokol, Sanjiv Sur, Bill T. Ameredes
      Pages 43-73
    5. Shiwan Shah, Gulshan Sharma
      Pages 75-80
    6. Ashwini P. Reddy, Meera R. Gupta
      Pages 81-103
    7. Sharon Petronella Croisant, Lauren Scott
      Pages 105-115
    8. William J. Calhoun
      Pages 117-122
  3. Genetics and Genomics in Asthma

    1. Front Matter
      Pages 123-123
    2. Joanne Sordillo, Benjamin A. Raby
      Pages 157-181
    3. Muhammad T. Salam
      Pages 183-199
  4. Proteomics, Metabolomics, and Systems Biology of Asthma

    1. Front Matter
      Pages 201-201
    2. John E. Wiktorowicz
      Pages 203-205
    3. Bruce A. Luxon
      Pages 207-220
    4. John E. Wiktorowicz, Mohammad Jamaluddin
      Pages 221-232
    5. Allan R. Brasier, Yingxin Zhao
      Pages 233-254
  5. Modeling Complex Data in Asthma

    1. Front Matter
      Pages 271-272
    2. Allan R. Brasier, Hyunsu Ju
      Pages 273-288
    3. Suresh K. Bhavnani, Justin Drake, Rohit Divekar
      Pages 289-305
  6. Biobehavioral Determinants in Asthma

    1. Front Matter
      Pages 307-308
    2. Joel N. Kline, Robert M. Rose
      Pages 309-319
    3. Mike Fortun, Kim Fortun, Brandon Costelloe-Kuehn, Tahereh Saheb, Daniel Price, Alison Kenner et al.
      Pages 321-332
  7. Conclusions and Future Directions

    1. Front Matter
      Pages 333-333
    2. William J. Calhoun, Allan R. Brasier
      Pages 335-343
  8. Back Matter
    Pages 345-354

About this book


Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.  These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response.  Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease.  An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma.  This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma.  As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​ 

Editors and affiliations

  • Allan R. Brasier
    • 1
  1. 1.Institute for Translational SciencesUniversity of Texas Medical BranchGalvestonUSA

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