Protein Deimination in Human Health and Disease

  • Anthony P. Nicholas
  • Sanjoy K. Bhattacharya

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Amanda S. Rohrbach, Sanja Arandjelovic, Kerri A. Mowen
    Pages 1-24
  3. Aase Haj Hensvold, Gudrun Reynisdottir, Anca I. Catrina
    Pages 25-40
  4. M. J. de Smit, J. Westra, W. Nesse, A. Vissink, A. J. van Winkelhoff, E. Brouwer
    Pages 69-82
  5. Julia Spengler, Dagmar Scheel-Toellner
    Pages 97-111
  6. Kenji Kizawa, Masaki Unno, Claus W. Heizmann, Hidenari Takahara
    Pages 129-148
  7. Gerburg Keilhoff, Anthony P. Nicholas
    Pages 149-164
  8. Claire Bradford, Anthony P. Nicholas, Nicola Woodroofe, Alison K. Cross
    Pages 165-185
  9. Eun-Kyoung Choi, Byungki Jang, Akihito Ishigami, Naoki Maruyama, Richard I. Carp, Yong-Sun Kim
    Pages 219-235
  10. Akihito Ishigami, Eun-Kyoung Choi, Yong-Sun Kim, Naoki Maruyama
    Pages 237-255
  11. Anthony P. Nicholas, Liang Lu, Michael Heaven, Inga Kadish, Thomas van Groen, Mary Ann Accaviti-Loper et al.
    Pages 257-280
  12. Patrizia Ferretti, Sigrun Lange, Kin Pong U, Gennadij Raivich
    Pages 281-294
  13. Di Ding, Mabel Enriquez-Algeciras, Vera L. Bonilha, Sanjoy K. Bhattacharya
    Pages 295-303
  14. Brian D. Cherrington, Sunish Mohanan, Scott A. Coonrod
    Pages 305-326
  15. Jialiang Liang, Patrizia Casaccia
    Pages 327-345
  16. Jennifer E. Grant, Hong Li
    Pages 347-365
  17. Sanna Turunen, Marja-Kaisa Koivula, Anthony P. Nicholas, Leila Risteli, Juha Risteli
    Pages 367-376
  18. Venkataraman Subramanian, Daniel J. Slade, Paul R. Thompson
    Pages 377-427
  19. Back Matter
    Pages 429-433

About this book


Deimination is a relatively new post-translational modification of proteins, whose recognition is ever-increasing. First linked to the pathology of rheumatoid arthritis (RA), deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase (PAD) family of enzymes.

Although the medical literature is rich with articles about the possible significance of deiminated proteins in RA, Protein Deimination in Human Health and Disease is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lung and nervous system, as well. As a result, this process has now been linked to numerous additional conditions besides RA, including cancer, glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord and peripheral nerve injury, Creutzfeldt-Jakob disease, among many others.

Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic.



aging auto-immune disease cancer epigenetics neurodegenerative disease peripheral nerve injury post-translational modification rheumatoid arthritis

Editors and affiliations

  • Anthony P. Nicholas
    • 1
  • Sanjoy K. Bhattacharya
    • 2
  1. 1.Department of NeurologyUniversity of Alabama at Birmingham and The Birmingham Veterans Administration Medical CenterBirminghamUSA
  2. 2.Bascom Palmer Eye InstituteUniversity of MiamiMIAMIUSA

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