Gadd45 Stress Sensor Genes

  • Dan A. Liebermann
  • Barbara Hoffman

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 793)

Table of contents

  1. Front Matter
    Pages i-x
  2. Jesús M. Salvador, Joshua D. Brown-Clay, Albert J. Fornace Jr.
    Pages 1-19
  3. Barbara Hoffman, Dan A. Liebermann
    Pages 21-33
  4. Ingo Schmitz
    Pages 51-68
  5. Ossie Geifman-Holtzman, Yali Xiong, Eliezer J. Holtzman
    Pages 121-129
  6. Back Matter
    Pages 131-134

About this book


Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  


gadd45 genes gene function proteins stress sensors stress signaling

Editors and affiliations

  • Dan A. Liebermann
    • 1
  • Barbara Hoffman
    • 2
  1. 1.Professor of BiochemistryTemple University School of MedicinePhiladelphiaUSA
  2. 2.Professor of BiochemistryTemple University School of MedicinePhiladelphiaUSA

Bibliographic information

Industry Sectors