© 2013

Advances in Chronic Lymphocytic Leukemia

  • Sami Malek
  • Provides a comprehensive review on chronic lymphocytic leukemia

  • Features paramount research in the field

  • Focuses on crucial aspects of CLL pathogenesis


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 792)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Andreas Agathangelidis, Stavroula Ntoufa, Kostas Stamatopoulos
    Pages 1-24
  3. Jan A. Burger
    Pages 25-45
  4. Peter Ouillette, Sami Malek
    Pages 47-86
  5. Alejandra Martínez-Trillos, Víctor Quesada, Neus Villamor, Xose S. Puente, Carlos López-Otín, Elías Campo
    Pages 87-107
  6. Martin Trbusek, Jitka Malcikova
    Pages 109-131
  7. Rita Shaknovich
    Pages 133-150
  8. Chris Fegan, Chris Pepper
    Pages 151-171
  9. Davide Rossi, Gianluca Gaidano
    Pages 173-191
  10. Asish K. Ghosh, Neil E. Kay
    Pages 215-239
  11. Jae H. Park, Renier J. Brentjens
    Pages 241-257
  12. Carsten U. Niemann, Jade Jones, Adrian Wiestner
    Pages 259-291
  13. Helen E. Speedy, Georgina Sava, Richard S. Houlston
    Pages 293-308
  14. Veronica Balatti, Yuri Pekarky, Lara Rizzotto, Carlo M. Croce
    Pages 309-325
  15. Back Matter
    Pages 327-334

About this book


Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course.  While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL.  In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings.  This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply.  Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings.

We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia. 


CLL Cancer research Chronic lymphocytic leukemia genotoxic

Editors and affiliations

  • Sami Malek
    • 1
  1. 1.Department of Internal MedicineUniversity of MichiganAnn ArborUSA

About the editors

Sami N. Malek is an Associate Professor at the Department of Internal Medicine at the University of Michigan Health System. Dr. Malek's research interests include basic and translational questions in Leukemia and Lymphoma. Well known in the field of CLL, Dr. Malek is well-published in the area and is invited to international conferences and seminars to give talks on the topic.

Bibliographic information

  • Book Title Advances in Chronic Lymphocytic Leukemia
  • Editors Sami Malek
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Advs Exp. Medicine, Biology
  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4614-8050-1
  • Softcover ISBN 978-1-4939-5389-9
  • eBook ISBN 978-1-4614-8051-8
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XI, 334
  • Number of Illustrations 1 b/w illustrations, 24 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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