Cholesterol and Presynaptic Glutamate Transport in the Brain

  • Tatiana Borisova

Part of the SpringerBriefs in Neuroscience book series (BRIEFSNEUROSCI, volume 12)

About this book

Introduction

Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders.  Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity.   In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits.​

Keywords

cholesterol glutamate transport neuroprotection presynaptic brain nerve terminals

Authors and affiliations

  • Tatiana Borisova
    • 1
  1. 1.Department of NeurochemistryPalladin Institute of Neurochemistry NAS of UkraineKievUkraine

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-7759-4
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-7758-7
  • Online ISBN 978-1-4614-7759-4
  • Series Print ISSN 2191-558X
  • Series Online ISSN 2191-5598
  • About this book
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