© 2013

Primates, Pathogens, and Evolution

  • Jessica F. Brinkworth
  • Kate Pechenkina
  • Integrates research from a broad range of fields on primate-pathogen molecular interactions, primate immune function, and primate-pathogen co-evolution

  • Provides a sound base of knowledge for future investigation of human and non-human primate evolution, immunity, and disease

  • Allows the specialist and educated lay-reader to understand and critically evaluate current data on differences in the molecular mechanics of primate immune response, pathogen-mediated primate evolution, and primate health


Table of contents

  1. Front Matter
    Pages i-x
  2. Jessica F. Brinkworth, Kate Pechenkina
    Pages 1-14
  3. Immunity and Primate Evolution

    1. Front Matter
      Pages 15-15
    2. Jessica F. Brinkworth, Mitchell Thorn
      Pages 17-64
    3. Jessica F. Brinkworth, Kirstin N. Sterner
      Pages 91-116
    4. Felicia Gomez, Wen-Ya Ko, Avery Davis, Sarah A. Tishkoff
      Pages 117-160
    5. Julie M. Allen, Cedric O. Worman, Jessica E. Light, David L. Reed
      Pages 161-186
  4. Emergence and Divergent Disease Manifestation

    1. Front Matter
      Pages 187-187
    2. Lai-Yee Wong, Zsolt Toth, Kevin F. Brulois, Kyung-Soo Inn, Sun Hwa Lee, Hye-Ra Lee et al.
      Pages 221-251
    3. José Luiz Catão-Dias, Sabrina Epiphanio, Maria Cecília Martins Kierulff
      Pages 253-289
    4. Edward J. D. Greenwood, Fabian Schmidt, Jonathan L. Heeney
      Pages 291-327
  5. Primates, Pathogens and Health

    1. Front Matter
      Pages 329-329
    2. Melanie Martin, Aaron D. Blackwell, Michael Gurven, Hillard Kaplan
      Pages 363-387
    3. Kristin N. Harper, Molly K. Zuckerman, Bethany L. Turner, George J. Armelagos
      Pages 389-409
  6. Back Matter
    Pages 411-428

About this book


The immune systems of humans and non-human primates have diverged such that these animals show inter- and intra-species variation in susceptibility, symptoms, and survival of particular infectious diseases. Variation in primate immunity is such that some major human pathogens - such as immunodeficiency viruses, herpesviruses and malaria-inducing species of Plasmodium - elicit striking differences in immune response between closely related species and within populations. Complex evolutionary processes that include interactions among the host, its pathogens and symbiont/commensal organisms have shaped these differences in immunity. The success of some pathogens in establishing persistent infections in humans and other primates has been determined not just by the molecular evolution of the pathogen and its interactions with the host, but also by the evolution of primate behavior and ecology, microflora, immune factors and the evolution of other biological systems. 

To explore how interactions between primates and their pathogens have shaped their mutual molecular evolution, Primates, Pathogens and Evolution brings together research that explores comparative primate immune function, the emergence of major and neglected primate diseases, primate-microorganism molecular interactions, and related topics. This book will be of interest to anyone curious as to why infectious diseases manifest differently in humans and their closest relatives. It will be of particular interest to scholars specializing in human and non-human primate evolution, epidemiology and immunology, and disease ecology. Primates, Pathogens and Evolution offers an overview and discussion of current findings on differences in the molecular mechanics of primate immune response, as well as on pathogen-mediated primate evolution and human and non-human primate health.


infectious diseases

Editors and affiliations

  • Jessica F. Brinkworth
    • 1
  • Kate Pechenkina
    • 2
  1. 1.Department of Pediatrics, CHU Saint-Justine Research CenterUniversity of MontrealMontreal, QCCanada
  2. 2.Department of AnthropologyQueens College, City University of New YNew YorkUSA

Bibliographic information