Autophagy and Cancer

  • Hong-Gang Wang

Part of the Current Cancer Research book series (CUCR, volume 8)

Table of contents

  1. Front Matter
    Pages i-xi
  2. William A. Dunn Jr., Laura A. Schroder, John P. Aris
    Pages 1-24
  3. Meiyan Jin, Daniel J. Klionsky
    Pages 25-45
  4. Susana Abreu, Jana Sanchez-Wandelmer, Fulvio Reggiori
    Pages 47-61
  5. Pui-Mun Wong, Xuejun Jiang
    Pages 63-93
  6. Hanlin Tao, Robert Taylor Jr., Xiangang Zeng, Shengkan Jin
    Pages 95-112
  7. Yoshinobu Ichimura, Masaaki Komatsu
    Pages 113-125
  8. Gregor M. Balaburski, Anna Budina, Maureen E. Murphy
    Pages 127-143
  9. Lindsey M. Silva, Jae U. Jung
    Pages 145-165
  10. Daolin Tang, Michael T. Lotze
    Pages 167-189
  11. Andrew Thorburn, Michael J. Morgan
    Pages 191-204
  12. Megan M. Young, Hong-Gang Wang
    Pages 205-224
  13. Hua Yang, Jessica A. Williams, Yifeng Hou, Menghang Xia, Ying-Hong Shi, Jia Fan et al.
    Pages 225-254
  14. Back Matter
    Pages 255-261

About this book


This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer.


autophagosomes autophagy cancer signal transduction

Editors and affiliations

  • Hong-Gang Wang
    • 1
  1. 1.Penn State College of Medicine, PharmacologyPenn State Hershey Cancer InstituteHersheyUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-6560-7
  • Online ISBN 978-1-4614-6561-4
  • Buy this book on publisher's site
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