Kisspeptin Signaling in Reproductive Biology

  • Alexander S. Kauffman
  • Jeremy T. Smith

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 784)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Kisspeptin Signaling In Vivo and In Vitro

    1. Front Matter
      Pages 1-1
    2. Robert A. Steiner
      Pages 3-7
    3. Michael N. Lehman, Stanley M. Hileman, Robert L. Goodman
      Pages 27-62
    4. Ali Abbara, Risheka Ratnasabapathy, Channa N. Jayasena, Waljit S. Dhillo
      Pages 63-87
    5. Oline K. Rønnekleiv, Martin J. Kelly
      Pages 113-131
    6. Suzy Drummond Carvalho Bianco, Ursula B. Kaiser
      Pages 133-158
    7. Antonia Kathryn Roseweir, Robert P. Millar
      Pages 159-186
    8. Letícia Gontijo Silveira, Ana Claudia Latronico, Stephanie Beth Seminara
      Pages 187-199
  3. Development and Regulation of Kisspeptin Neurons

    1. Front Matter
      Pages 219-219
    2. Sheila J. Semaan, Kristen P. Tolson, Alexander S. Kauffman
      Pages 221-252
    3. Ei Terasawa, Kathryn A. Guerriero, Tony M. Plant
      Pages 253-273
    4. Jeremy T. Smith
      Pages 275-295
    5. Hiroaki Okamura, Hiroko Tsukamura, Satoshi Ohkura, Yoshihisa Uenoyama, Yoshihiro Wakabayashi, Kei-ichiro Maeda
      Pages 297-323
    6. Víctor M. Navarro
      Pages 325-347
    7. Meenakshi Alreja
      Pages 349-362
    8. Juan Manuel Castellano, Manuel Tena-Sempere
      Pages 363-383
    9. Iain J. Clarke, Alain Caraty
      Pages 411-430
    10. Pasha Grachev, Xiao Feng Li, Kevin O’Byrne
      Pages 431-454
    11. William H. Colledge, Joanne Doran, Hua Mei
      Pages 481-503
  4. Back Matter
    Pages 505-514

About this book


Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood.  This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known.  The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function.  Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.

Editors and affiliations

  • Alexander S. Kauffman
    • 1
  • Jeremy T. Smith
    • 2
  1. 1., Department of Reproductive MedicineUniversity of California, San DiegoLa JollaUSA
  2. 2.School of Anatomy, Physiology and Human BiologyThe University of Western AustraliaNedlandsAustralia

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