Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems

  • Marc Thiriet

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Marc Thiriet
    Pages 1-18
  3. Marc Thiriet
    Pages 19-52
  4. Marc Thiriet
    Pages 53-175
  5. Marc Thiriet
    Pages 177-187
  6. Marc Thiriet
    Pages 189-269
  7. Marc Thiriet
    Pages 271-348
  8. Marc Thiriet
    Pages 349-380
  9. Marc Thiriet
    Pages 381-452
  10. Marc Thiriet
    Pages 453-603
  11. Marc Thiriet
    Pages 605-673
  12. Marc Thiriet
    Pages 675-747
  13. Marc Thiriet
    Pages 749-787
  14. Marc Thiriet
    Pages 789-804
  15. Marc Thiriet
    Pages 805-812
  16. Back Matter
    Pages 813-962

About this book


The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models.  The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.

Reviews structure and function of major constituents of the circulatory and respiratory apparatus

Describes major cellular processes involved in signaling, interactions, and adaptive responses of physiological conduits

Integrates biology, chemistry, and physics for the multidisciplinary exploration and modeling of physiological flows

Focuses on mechanotransduction-induced regulation


blood flow behavior blood flow prediction cardiovascular systems modeling cell signalling pathways ion and molecule carriers described modeling respiratory function modeling simulation of flows physiological flows receptors ligands signaling mediators explained ventilatory systems modeling

Authors and affiliations

  • Marc Thiriet
    • 1
  1. 1.Laboratoire Jacques-Louis Lions, Institut Universitaire de FranceUniversité Pierre et Marie CurieParisFrance

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-1-4614-5965-1
  • Online ISBN 978-1-4614-5966-8
  • Series Print ISSN 2193-1682
  • Series Online ISSN 2193-1690
  • Buy this book on publisher's site
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