Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

  • Denis Corbeil

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 777)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Biology of Prominins

    1. Front Matter
      Pages 1-1
    2. Denis Corbeil, Jana Karbanová, Christine A. Fargeas, József Jászai
      Pages 3-24
    3. Christine A. Fargeas
      Pages 25-40
    4. Nagananda Gurudev, Mareike Florek, Denis Corbeil, Elisabeth Knust
      Pages 55-71
    5. Kouichi Tabu, Norihisa Bizen, Tetsuya Taga, Shinya Tanaka
      Pages 73-85
  3. Prominin-1/CD133 and Stem Cells

    1. Front Matter
      Pages 87-87
    2. Rupert Handgretinger, Selim Kuçi
      Pages 99-111
    3. Mariusz Z. Ratajczak, Kasia Mierzejewska, Janina Ratajczak, Magda Kucia
      Pages 125-141
  4. Prominin-1/CD133 and the Cancer Stem Cell Hypothesis

    1. Front Matter
      Pages 143-143
    2. Alessandro Sgambato, Maddalena Corbi, Maria Svelto, Emanuele Caredda, Achille Cittadini
      Pages 145-166
    3. Davide Pellacani, Emma E. Oldridge, Anne T. Collins, Norman J. Maitland
      Pages 167-184
    4. Aurelio Lorico, Javier Mercapide, Germana Rappa
      Pages 197-211
  5. Future Perspectives: From Basic Research to Medical Application

    1. Front Matter
      Pages 213-213
    2. Mirella Meregalli, Andrea Farini, Marzia Belicchi, Yvan Torrente
      Pages 229-243
  6. Back Matter
    Pages 245-250

About this book


Since its first description fifteen years ago as a novel antigen of neural and hematopoietic stem cells, prominin-1 (alias CD133) has emerged concomitantly with stem and cancer stem cell research as an essential cell surface marker allowing identification and isolation of cells with stem cell properties. Although the physiological function of prominin-1 and the other members of prominin family remains elusive, its study has revealed new biological features regarding stem cells, cancer stem cells and photoreceptors. The latter cell type is illustrated by the association of mutations in prominin-1 (PROM1) gene with retinal degenerations including Stargardt-like macular dystrophy and retinitis pigmentosa. This book discusses these issues with contributions from leading experts in molecular and cellular biology, stem cells and tissue engineering. It also covers the potential role of prominin-1–positive stem cells in regenerative medicine, and its use as a biomarker of cancers originating from various organ systems and/or molecular target in cancer stem cell therapy. This book is an essential concise guide to the latest discoveries on prominin-1 and the applications in various medical research fields such as stem and cancer stem cells.
Denis Corbeil holds a PhD in Biochemistry (University of Montreal, Canada). He is head of Tissue Engineering Laboratories, Biotechnological Centre (BIOTEC), Technische Universität Dresden, Dresden, Germany.


gene regulation hematopoietic stem cells progenitor cells prominins

Editors and affiliations

  • Denis Corbeil
    • 1
  1. 1., Biotechnological Centre (BIOTEC)Dresden University of TechnologyDresdenGermany

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