© 2016

Metastatic Bone Disease

An Integrated Approach to Patient Care

  • R. Lor Randall
  • Covers all aspects of surgical and medical intervention in metastatic bone disease for orthopedic surgeons and oncologists

  • Presents mechanistic biology, work-up, medical therapy, radiation and interventional oncology, principles and techniques of orthopedic surgical oncology and emerging technologies

  • Features rich and detailed images for diagnostic and referential purposes


Table of contents

  1. Front Matter
    Pages i-xiii
  2. The Problem

    1. Front Matter
      Pages 1-1
    2. Robert U. Ashford, R. Lor Randall
      Pages 3-11
  3. Biology of Metastases and Tissue of Origin Considerations

    1. Front Matter
      Pages 13-13
    2. Antonella Chiechi, Theresa A. Guise
      Pages 15-35
    3. Patrick W. O’Donnell, Denis R. Clohisy
      Pages 37-44
    4. Sarah Colonna, Theresa L. Werner
      Pages 45-54
    5. Jonathan D. Tward
      Pages 55-64
    6. Shamus R. Carr
      Pages 65-69
    7. Patrik Luzny, Christopher Dechet
      Pages 71-83
    8. Elie Klam, Dev Abraham
      Pages 85-88
    9. Srinivas K. Tantravahi, Tibor Kovacsovics
      Pages 89-100
  4. Work-Up for Patients with Suspected Metastatic Bone Disease

    1. Front Matter
      Pages 101-101
    2. Bruce T. Rougraff, Terence J. Cudahy
      Pages 103-109
    3. Daniel M. Lerman
      Pages 111-117
  5. Medical Therapy

    1. Front Matter
      Pages 119-119
    2. Z. Deniz Olgun, Arianna Gianakos, Jonathan E. Jo, Joseph M. Lane
      Pages 121-129
    3. Anna R. Cooper, Wakenda Tyler, Emily E. Carmody
      Pages 131-142
  6. Supportive Oncology

    1. Front Matter
      Pages 143-143

About this book


Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and biotargeting. The heart of the book presents oncological approaches (supportive, radiation, and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.


Ablation technologies Biotargeting Bisphosphonates Bone cancer Bone tumor Cement augmentation Interventional oncology Metastatic bone disease Myeloma Neoplasm Orthopedic oncology Osteoblastic metastases Osteolytic metastases Radiation oncology

Editors and affiliations

  • R. Lor Randall
    • 1
  1. 1.Huntsman Cancer InstituteThe University of UtahSalt Lake CityUSA

About the editors

R. Lor Randall, MD, FACS, The L.B. & Olive S. Young Endowed Chair for Cancer Research Director, Sarcoma Services & Medical Director, HCI Surgical Services Chief, SARC Lab & Fellowships Co-Leader, Sarcoma Disease Oriented Research Team, Professor of Orthopaedics, Primary Children's Hospital & Huntsman Cancer Institute, The University of Utah Salt Lake City, UT.

Bibliographic information

  • Book Title Metastatic Bone Disease
  • Book Subtitle An Integrated Approach to Patient Care
  • Editors R. Lor Randall
  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-4614-5661-2
  • Softcover ISBN 978-1-4939-7933-2
  • eBook ISBN 978-1-4614-5662-9
  • Edition Number 1
  • Number of Pages XIII, 368
  • Number of Illustrations 50 b/w illustrations, 35 illustrations in colour
  • Topics Orthopedics
  • Buy this book on publisher's site
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