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© 2012

Tandem Repeat Polymorphisms

Genetic Plasticity, Neural Diversity and Disease

  • Anthony J. Hannan
  • Focuses on key aspects of TRPs in health and disease

  • Provides a detailed discussion of repeat sequences as mutable sites providing genetic variability upon which natural selection can act

  • Provides insights into how expanded polyalanine in specific proteins leads to developmental abnormalities and neurocognitive dysfunction

Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Anthony J. Hannan
    Pages 1-9
  3. Sterling M. Sawaya, Andrew T. Bagshaw, Emmanuel Buschiazzo, Neil J. Gemmell
    Pages 41-54
  4. Clare L. van Eyk, Robert I. Richards
    Pages 55-77
  5. Danuta Loesch, Randi Hagerman
    Pages 78-114
  6. Amy L. Robertson, Stephen P. Bottomley
    Pages 115-124
  7. Saskia Polling, Andrew F. Hill, Danny M. Hatters
    Pages 125-140
  8. Henry J. Waldvogel, Doris Thu, Virginia Hogg, Lynette Tippett, Richard L. M. Faull
    Pages 141-152
  9. Jeffrey D. Zajac, Mark Ng Tang Fui
    Pages 153-168
  10. Louise A. Corben, Nellie Georgiou-Karistianis, John L. Bradshaw, Marguerite V. Evans-Galea, Andrew J. Churchyard, Martin B. Delatycki
    Pages 169-184
  11. Cheryl Shoubridge, Jozef Gecz
    Pages 185-203
  12. Back Matter
    Pages 205-208

About this book

Introduction

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.

Keywords

Anthony J. Hannan Polymorphism Repeat Polymorphisms TRPs Tandem

Editors and affiliations

  • Anthony J. Hannan
    • 1
  1. 1.Florey Neuroscience Institutes, Melbourne Brain CentreUniversity of MelbourneParkvilleAustralia

About the editors

ANTHO NY J. HANNAN is Head of the Neural Plasticity Laboratory, Florey Neuroscience Institutes and Associate Professor at the University of Melbourne, Parkville, Australia. Following undergraduate and PhD degrees at the University of Sydney, Anthony received postdoctoral neuroscience training at the University of Oxford, supported by a Nuffield Medical Fellowship. He currently holds an Australian Research Council (ARC) Future Fellowship (FT3) and an Honorary Senior Research Fellowship from the National Health and Medical Research Council (NHMRC). Main research interests include pathogenic mechanisms mediating Huntington’s disease and related tandem repeat expansion disorders, as well as other cognitive and psychiatric illnesses. In his laboratory, experimental models of gene‑environment interactions are used to explore experience‑dependent plasticity in the healthy and diseased brain.

Bibliographic information

  • Book Title Tandem Repeat Polymorphisms
  • Book Subtitle Genetic Plasticity, Neural Diversity and Disease
  • Editors Anthony J. Hannan
  • Series Title Advances in Experimental Medicine and Biology
  • DOI https://doi.org/10.1007/978-1-4614-5434-2
  • Copyright Information Landes Bioscience and Springer Science+Business Media New York 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4614-5433-5
  • Softcover ISBN 978-1-4939-5448-3
  • eBook ISBN 978-1-4614-5434-2
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIX, 208
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Biomedicine, general
    Neurosciences
    Gene Function
  • Buy this book on publisher's site
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