Proceedings of the Fourth Seattle Symposium in Biostatistics: Clinical Trials

  • Thomas R. Fleming
  • Bruce S. Weir

Part of the Lecture Notes in Statistics book series (LNS, volume 1205)

Also part of the Lecture Notes in Statistics - Proceedings book sub series (LNSP, volume 1205)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Biomarkers: Role in the Design and Interpretation of Clinical Trials

  3. Biomarkers: Issues in Individualized Therapy

  4. Issues in Multi-Regional Clinical Trials

  5. Safety

  6. Special Topics

    1. Front Matter
      Pages 175-175
    2. B. S. Weir, P. J. Heagerty
      Pages 209-245
  7. Back Matter
    Pages 247-249

About these proceedings


This volume contains a selection of chapters based on papers presented at the Fourth Seattle Symposium on Biostatistics: Clinical Trials. These biostatistical symposiums, which unite leading researchers every five years, represent important developments in field. The Fourth Seattle Symposium was held in 2010 to celebrate the 40th anniversary of the University of Washington School of Public Health and Community Medicine. The Symposium featured keynote lectures by Robert O’Neill, Ross Prentice and Robert Temple, as well as invited talks by Jesse Berlin, Christy Chuang-Stein, David DeMets, Bill DuMouchel, Susan Ellenberg, Thomas Fleming, Laurence Freedman, Margaret Pepe, Steve Self, Richard Simon, Bruce Weir, John Whittaker and Janet Wittes.  Invited panelists included Jesse Berlin, Bruce Binkowitz, Christy Chuang-Stein, Bill DuMouchel, Susan Ellenberg, Thomas Fleming, Henry Fuchs, Dominic Labriola, Robert O’Neill, Robert Temple and Janet Wittes. The thoroughly peer-reviewed papers and material from short courses that are showcased in this volume represent the theme of the symposium, clinical trials. These papers encompass recent methodological advances on several important topics, summaries of the state of the art of methodology in key areas of clinical trials, as well as innovative applications of the existing theory and methods. This volume will be a valuable reference for researchers and practitioners in the field of clinical trials.


Bioinformatics Biostatistics Clinical Trials

Editors and affiliations

  • Thomas R. Fleming
    • 1
  • Bruce S. Weir
    • 2
  1. 1.University of WashingtonSeattleUSA
  2. 2.University of WashingtonSeattleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Mathematics and Statistics
  • Print ISBN 978-1-4614-5244-7
  • Online ISBN 978-1-4614-5245-4
  • Series Print ISSN 0930-0325
  • Buy this book on publisher's site
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