© 2013

Cardiac Adaptations

Molecular Mechanisms

  • Bohuslav Ostadal
  • Naranjan S. Dhalla


  • Focuses on the molecular and biochemical mechanisms, which are intimately involved in modifying the myocardial characteristics in health and disease

  • Summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation

  • Pulls together the rapidly developing basic and translational information on adaptive mechanisms


Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 4)

Table of contents

  1. Front Matter
    Pages i-xvii

    1. Front Matter
      Pages 1-1
    2. Bohuslav Ostadal
      Pages 3-18
    3. Patricia Roche, Michael P. Czubryt, Jeffrey T. Wigle
      Pages 19-39
    4. Zivorad Pesevski, David Sedmera
      Pages 41-57
    5. Jérôme Piquereau, Marta Novotova, Anne Garnier, Frédéric Joubert, Vladimir Veksler, Renée Ventura-Clapier
      Pages 79-98
    6. Bohuslav Ostadal, Ivana Ostadalova, Zuzana Charvatova, Frantisek Kolar
      Pages 99-110
    7. Paul D. Chantler, Edward G. Lakatta
      Pages 111-144

    1. Front Matter
      Pages 145-145
    2. Alison L. Müller, Naranjan S. Dhalla
      Pages 147-166
    3. Vojtech Melenovsky
      Pages 167-199
    4. Melissa R. Dent, Vijayan Elimban, Amrit Malik, Paramjit S. Tappia, Naranjan S. Dhalla
      Pages 201-212
    5. Jean-Paul Richalet
      Pages 233-249
    6. Jaroslav Kuneš, Ivana Vaněčková, Michaela Kadlecová, Michal Behuliak, Zdenka Dobešová, Josef Zicha
      Pages 251-267
    7. Dirk J. Duncker, Elza D. van Deel, Monique C. de Waard, Jolanda van der Velden
      Pages 269-287
    8. Aaron L. Baggish
      Pages 289-302

    1. Front Matter
      Pages 303-303
    2. Adriana Adameova, Paramjit S. Tappia, Naranjan S. Dhalla
      Pages 305-324

About this book


The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases. 

The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging.  The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations.  The third section of this volume highlights the roles of sympathetic nervous system with respect to α-adrenoceptor and β-adrenoceptor mechanisms in the development of cardiac hypertrophy.  Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.


biochemical mechanisms cardiac development molecular biology myocardial physiology signal transduction

Editors and affiliations

  • Bohuslav Ostadal
    • 1
  • Naranjan S. Dhalla
    • 2
  1. 1.Czech Republic, Institute of PhysiologyAcademy of Sciences of thePragueCzech Republic
  2. 2.St. Boniface General Hospital, Research CentreInstitute of Cardiovascular SciencesWinnipegCanada

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