DNA Helicases and DNA Motor Proteins

  • Maria Spies

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 767)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Colin G. Wu, Maria Spies
    Pages 1-16
  3. Kevin D. Raney, Alicia K. Byrd, Suja Aarattuthodiyil
    Pages 17-46
  4. David C. Beyer, Mohamed Karem Ghoneim, Maria Spies
    Pages 47-73
  5. Barbara Medagli, Silvia Onesti
    Pages 75-95
  6. Peter McGlynn
    Pages 97-121
  7. Avvaru N. Suhasini, Robert M. Brosh Jr.
    Pages 123-144
  8. Nicolai Balle Larsen, Ian D. Hickson
    Pages 161-184
  9. James M. Daley, Hengyao Niu, Patrick Sung
    Pages 185-202
  10. Jochen Kuper, Caroline Kisker
    Pages 203-224
  11. Gaëlle Demarre, Elisa Galli, François-Xavier Barre
    Pages 245-262
  12. Jaya Yodh
    Pages 263-295
  13. Kevin D. Raney, Alicia K. Byrd, Suja Aarattuthodiyil
    Pages E1-E1
  14. Back Matter
    Pages 297-299

About this book


In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines.

The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

Editors and affiliations

  • Maria Spies
    • 1
  1. 1., Department of BiochemistryUniversity of Iowa Carver College of MedIowa CityUSA

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