Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Proceedings of the 6th International Conference on Sodium Calcium Exchange

  • Lucio Annunziato

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 961)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Historical Perspective

    1. Front Matter
      Pages 1-1
    2. Mordecai P. Blaustein
      Pages 3-15
    3. Debora A. Nicoll, Michela Ottolia, Joshua I. Goldhaber, Kenneth D. Philipson
      Pages 17-23
  3. Structural and Functional Aspects of NCX

  4. Structural and Functional Aspects of NCKX

  5. Genetic and Epigenetic Regulation

    1. Front Matter
      Pages 123-123
    2. Donald R. Menick, Mona S. Li, Olga Chernysh, Ludivine Renaud, Denise Kimbrough, Harinath Kasiganesan et al.
      Pages 125-135
    3. Valeria Valsecchi, Giuseppe Pignataro, Rossana Sirabella, Carmela Matrone, Francesca Boscia, Antonella Scorziello et al.
      Pages 137-145
  6. Regulatory Mechanisms of NCX

    1. Front Matter
      Pages 147-147
    2. Luis Beaugé, Reinaldo DiPolo, Mariana Bollo, Alexandra Cousido, Graciela Berberián, Alberto Podjarny
      Pages 149-161
    3. Joseph Y. Cheung, Xue-Qian Zhang, Jianliang Song, Erhe Gao, Tung O. Chan, Joseph E. Rabinowitz et al.
      Pages 175-190
  7. Subcellular Localization and Function of NCX in Ca2+-Storing Organelles and Mitochondria

    1. Front Matter
      Pages 191-191
    2. Bongju Kim, Ayako Takeuchi, Orie Koga, Masaki Hikida, Satoshi Matsuoka
      Pages 193-201
    3. Antonella Scorziello, Claudia Savoia, Agnese Secondo, Francesca Boscia, Maria Josè Sisalli, Alba Esposito et al.
      Pages 203-209
  8. NCX in Neurodegenerative Diseases

    1. Front Matter
      Pages 211-211
    2. Pasquale Molinaro, Mauro Cataldi, Ornella Cuomo, Davide Viggiano, Giuseppe Pignataro, Rossana Sirabella et al.
      Pages 213-222
    3. Giuseppe Pignataro, Ornella Cuomo, Antonio Vinciguerra, Rossana Sirabella, Elga Esposito, Francesca Boscia et al.
      Pages 223-240
    4. Alison Wood-Kaczmar, Emma Deas, Nicholas W. Wood, Andrey Y. Abramov
      Pages 241-249
  9. Emerging Role of NCX Activity in Immune and Glial Cells

    1. Front Matter
      Pages 265-265
    2. Héctor Rojas, Claudia Colina, Magaly Ramos, Gustavo Benaim, Erica Jaffe, Carlo Caputo et al.
      Pages 267-274
    3. Hannah Rahamimoff, Benayahu Elbaz, Michael Valitsky, Mahdi Khatib, Marina Eskin-Schwartz, Daniela Elmaz
      Pages 275-287
    4. Mami Noda, Masataka Ifuku, Yuki Mori, Alexei Verkhratsky
      Pages 289-294
    5. Alexei Verkhratsky, Mami Noda, Vladimir Parpura, Sergei Kirischuk
      Pages 295-305
    6. Francesca Boscia, Carla D’Avanzo, Anna Pannaccione, Agnese Secondo, Antonella Casamassa, Luigi Formisano et al.
      Pages 307-316
    7. Rosaria I. Staiano, Francescopaolo Granata, Agnese Secondo, Angelica Petraroli, Stefania Loffredo, Lucio Annunziato et al.
      Pages 317-326
  10. NCX in the Heart and Vascular Smooth Muscle

    1. Front Matter
      Pages 327-327
    2. Donald W. Hilgemann, Mei-Jung Lin, Michael Fine, Gary Frazier, Hao-Ran Wang
      Pages 345-352
  11. NCX Role in Hypertension, Heart Failure, Ischemia-Reperfusion, Arrhythmias and Diabetes

    1. Front Matter
      Pages 353-353
    2. Maria V. Pulina, A. Zulian, Sergey G. Baryshnikov, Cristina I. Linde, Eiji Karashima, John M. Hamlyn et al.
      Pages 365-374
    3. Karin R. Sipido, Károly Acsai, Gudrun Antoons, Virginie Bito, Niall Macquaide
      Pages 375-383
    4. André Herchuelz, Evrard Nguidjoe, Lin Jiang, Nathalie Pachera
      Pages 385-394
  12. NCX Partners in Ionic Homeostasis: ASIC, NMDA, NHE and TRPC

    1. Front Matter
      Pages 395-395
    2. Viktoria Lukashova, Tushare Jinadasa, Alina Ilie, David Verbich, Ellis Cooper, John Orlowski
      Pages 397-410
    3. Xiang-Ping Chu, Zhi-Gang Xiong
      Pages 419-431
    4. John F. MacDonald, Jillian C. Belrose, Yu-Feng Xie, Michael F. Jackson
      Pages 433-447
  13. Antonella Scorziello, Claudia Savoia, Agnese Secondo, Francesca Boscia, Maria Josè Sisalli, Alba Esposito et al.
    Pages E1-E1

About this book


This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011.

The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.

The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.


Lucio Annunziato is Professor of Pharmacology and chairman of the Department of Neuroscience in the School of Medicine at the “Federico II” University of Naples, Italy. He is coordinator of the University’s Neuroscience Ph.D. program. He is also past-president of the Italian Society for Neuroscience. Dr. Annunziato has authored more that 190 full papers in peer reviewed international journals in the field of neuroscience and molecular pharmacology of plasmamembrane transporters and ionic channels involved in the pathophysiology of stroke and other neurodegenerative diseases. 

Editors and affiliations

  • Lucio Annunziato
    • 1
  1. 1.Dipto. Neuroscienze e diUniversità di Napoli Fac. Medicina e ChirurgiaNapoliItaly

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