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Atherosclerosis Drug Discovery

  • Charles E. Day

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)

Table of contents

  1. Front Matter
    Pages i-x
  2. Primate Models

  3. Rabbit Models

    1. Front Matter
      Pages 121-121
    2. David Kritchevsky, Shirley A. Tepper, Jon A. Story
      Pages 143-147
    3. Y. S. Kwak, K. T. Lee, D. N. Kim
      Pages 149-167
    4. Joseph D. Pool, John L. Gainer, Guy M. Chisolm III
      Pages 205-211
  4. Rodent Models

    1. Front Matter
      Pages 213-213
    2. Paul E. Schurr, John R. Schultz, Charles E. Day
      Pages 215-229
    3. Charles E. Day, Paul E. Schurr, William E. Heyd, Daniel Lednicer
      Pages 231-249
    4. W. A. Phillips, J. M. Ratchford, J. R. Schultz
      Pages 251-265
    5. Nozomu Takeuchi, Masami Ito, Yuichi Yamamura
      Pages 267-288
    6. M. G. Soret, M. C. Blanks, G. C. Gerritsen, C. E. Day, E. M. Block
      Pages 329-343
  5. Avian Models

    1. Front Matter
      Pages 345-345
    2. M. G. Soret, T. Peterson, K. P. Chapman, W. W. Stafford, C. E. Day, E. M. Block
      Pages 357-376
  6. Tissue Culture

    1. Front Matter
      Pages 403-403
    2. Harry W. Chen, Andrew A. Kandutsch
      Pages 405-417
    3. R. J. Bing, J. S. M. Sarma, R. Fischer, S. Ikeda
      Pages 419-435
    4. R. L. Jackson, O. Stein, M. C. Glangeaud, M. Fainaru, A. M. Gotto, Y. Stein
      Pages 453-461
  7. Back Matter
    Pages 463-467

About this book

Introduction

Although atherosclerosis is the leading cause of death in the so-called affluent societies, there is presently no drug in our pharmacologic armamentarium against disease to either prevent or reverse this insidious killer and debilitant of human lives. Because of this void the First Brook Lodge Symposium on Anti­ Atherosclerosis Drug Discovery was convened at Brook Lodge in Augusta, Michigan, August 13-15, 1975. The symposium was sponsored by The Upjohn Company and was international in scope, with investi­ gators attending from such countries as England, Japan, Belgium, and Italy. The symposium focused on the problems associated with the discovery and evaluation of new drugs effective in preventing or reversing atherosclerosis. The thrust of material is centered around animal models useful as tools in the search and evaluation of new drugs. Broadly categorized, the models are nonhuman primates, rabbits, rodents, quail, and tissue culture. The material is a mix of studies on serum lipids and, more importantly, of studies on the artery, irrespective of serum lipid levels. The prevention of arterial lesions, not reduction of serum lipids, is emphasized. A review of all anti-atherosclerotic agents, with the exception of hypolipidemic agents, is included in this volume of the proceedings of the symposium.

Keywords

Lipoprotein artery atherosclerosis death drug drug discovery drugs evaluation lipide pharmacology prevention tissue

Editors and affiliations

  • Charles E. Day
    • 1
  1. 1.Atherosclerosis ResearchThe Upjohn CompanyKalamazooUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-4618-7
  • Copyright Information Springer-Verlag US 1976
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-9309-3
  • Online ISBN 978-1-4614-4618-7
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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