Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

  • Marc Thiriet

Table of contents

  1. Front Matter
    Pages i-xv
  2. Marc Thiriet
    Pages 1-6
  3. Marc Thiriet
    Pages 7-107
  4. Marc Thiriet
    Pages 109-135
  5. Marc Thiriet
    Pages 137-173
  6. Marc Thiriet
    Pages 311-378
  7. Marc Thiriet
    Pages 379-386
  8. Marc Thiriet
    Pages 387-463
  9. Marc Thiriet
    Pages 647-819
  10. Marc Thiriet
    Pages 821-909
  11. Marc Thiriet
    Pages 911-918
  12. Back Matter
    Pages 919-1064

About this book


The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.

Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.  Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.

Reviews signaling pathways in the regulation of circulatory and respiratory function

Describes ion and molecular carriers and receptors

Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows


blood flow behavior blood flow prediction cardiovascular systems modeling cell signalling pathways ion and molecule carriers described modeling respiratory function modeling simulation of flows physiological flows receptors ligands signaling mediators explained ventilatory systems modeling

Authors and affiliations

  • Marc Thiriet
    • 1
  1. 1.Laboratoire Jacques-Louis Lions, Institut Universitaire de FranceUniversité Pierre et Marie CurieParisFrance

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-1-4614-4369-8
  • Online ISBN 978-1-4614-4370-4
  • Series Print ISSN 2193-1682
  • Series Online ISSN 2193-1690
  • Buy this book on publisher's site
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