p53 in the Clinics

  • Pierre Hainaut
  • Magali Olivier
  • Klas G. Wiman

Table of contents

  1. Front Matter
    Pages i-x
  2. Lukasz F. Grochola, Jorge Zeron-Medina, Emmanouela Repapi, Alexander E. Finlayson, Ying Cai, Gurinder Singh Atwal et al.
    Pages 25-46
  3. Masha V. Poyurovsky, Carol Prives
    Pages 47-64
  4. Massimiliano Agostini, Alessandro Rufini, Edward T. W. Bampton, Francesca Bernassola, Gerry Melino, Richard A. Knight
    Pages 65-76
  5. Tamara Terzian, Guillermina Lozano
    Pages 77-93
  6. Wolfgang Deppert, Genrich Tolstonog
    Pages 109-126
  7. Anita Langerød, Magali Olivier, Anne-Lise Børresen-Dale
    Pages 147-165
  8. Doua Bakry, David Malkin
    Pages 167-188
  9. Robert E. Sobol, Yong-Song Guan, Long-Jiang Li, Wei-Wei Zhang, Zhaohui Peng, Kerstin B. Menander et al.
    Pages 189-208
  10. Anna R. McCarthy, Sonia Lain
    Pages 209-229
  11. Vera V. Grinkevich, Andreas Warnecke, Galina Selivanova
    Pages 231-255
  12. Jinfeng Shen, Vladimir J. N. Bykov, Klas G. Wiman
    Pages 257-273
  13. Hakim Echchannaoui, Matthias Theobald
    Pages 275-287
  14. Daniela Kandioler, Sonja Kappel, Brigitte Wolf
    Pages 289-303
  15. Philippe Bertheau, Jean-François Fléjou, Yves Allory, Pascale Varlet, Sylvie Lantuejoul, Louis-François Plassa et al.
    Pages 305-326
  16. Maria Isabel Waddington Achatz, Patricia Ashton-Prolla
    Pages 327-343
  17. Back Matter
    Pages 345-355

About this book


With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on cancer management and therapy. This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application.

p53 in the Clinics follows the success of  25 Years of p53 Research and condensates in a series of authoritative chapters the considerable progress on the applications of p53 into the clinics and the substantial advances on diseases caused by inheritance of p53 defects, on somatic p53 mutations as biomarkers in molecular pathology, on progress in gene therapy and on developments of innovative drugs and clinical trials. This volume will appeal to a wide audience of students and professionals in basic and clinical cancer research and treatment, and will highlight the exciting “next steps” in p53 research and applications.


TP53 cancer research chromosome 17 protein kinase tumor suppressor protein ubiquitin ligases

Editors and affiliations

  • Pierre Hainaut
    • 1
  • Magali Olivier
    • 2
  • Klas G. Wiman
    • 3
  1. 1.International Prevention Research InstitLyonFrance
  2. 2.International Agency for Cancer ResearchLyonFrance
  3. 3.Cancer Center Karolinska (CCK), Dept. Oncology and PathologyKarolinska InstituteStockholmSweden

Bibliographic information

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