New Technologies for Toxicity Testing

  • Michael Balls
  • Robert D. Combes
  • Nirmala Bhogal

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 745)

Table of contents

  1. Front Matter
    Pages i-xxviii
  2. Tina C. Stummann, Susanne Bremer
    Pages 14-25
  3. Uwe Marx
    Pages 26-46
  4. Kevin M. Shakesheff, Felicity R. A. J. Rose
    Pages 47-57
  5. Amanda M. Schrand, Liming Dai, John J. Schlager, Saber M. Hussain
    Pages 58-75
  6. John C. Lipscomb, Sami Haddad, Torka Poet, Kannan Krishnan
    Pages 76-95
  7. Robert D. Combes
    Pages 96-116
  8. Shivang R. Dave, Collin C. White, Xiaohu Gao, Terrance J. Kavanagh
    Pages 117-137
  9. Tommaso Sbrana, Arti Ahluwalia
    Pages 138-153
  10. Michel Bouvier d’Yvoire, Susanne Bremer, Silvia Casati, Mara Ceridono, Sandra Coecke, Raffaella Corvi et al.
    Pages 154-180
  11. Yuan Wen, Xudong Zhang, Shang-Tian Yang
    Pages 181-209
  12. Daniel A. Casciano
    Pages 210-220
  13. Back Matter
    Pages 255-258

About this book


The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.


Balls New technology Testing technology Toxicity technology Toxicity testing

Editors and affiliations

  • Michael Balls
    • 1
  • Robert D. Combes
    • 2
  • Nirmala Bhogal
    • 3
  1. 1.FRAMENottinghamUK
  2. 2.NorwichUK
  3. 3.NottinghamUK

Bibliographic information

  • DOI
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-3054-4
  • Online ISBN 978-1-4614-3055-1
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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