Self and Nonself

  • Carlos López-Larrea

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 738)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Jesús Martínez-Borra, Segundo González, Carlos López-Larrea
    Pages 1-13
  3. Nao Jounai, Kouji Kobiyama, Fumihiko Takeshita
    Pages 60-78
  4. Ian A. Dubery, Natasha M. Sanabria, Ju-Chi Huang
    Pages 79-107
  5. Philip J. Kear, Bruce McClure
    Pages 108-123
  6. Yasunobu Miyake, Sho Yamasaki
    Pages 144-152
  7. Vipul M. Parmar, Martin Schröder
    Pages 153-168
  8. Jesús Martínez-Borra, Carlos López-Larrea
    Pages 169-184
  9. Nadia Danilova
    Pages 218-235
  10. Vincenzo Calvanese, Ester Lara, Mario F. Fraga
    Pages 236-255
  11. Jesús Martínez-Borra, Carlos López-Larrea
    Pages 277-289
  12. James S. Ruff, Adam C. Nelson, Jason L. Kubinak, Wayne K. Potts
    Pages 290-313
  13. Back Matter
    Pages 315-320

About this book


In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.


Immunology López-Larrea Self-Nonself Recognition

Editors and affiliations

  • Carlos López-Larrea
    • 1
  1. 1.Department of ImmunologyHospital Universitario Central de AsturiasOviedoSpain

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