Caveolins and Caveolae

Roles in Signaling and Disease Mechanisms

  • Jean-François Jasmin
  • Philippe G. Frank
  • Michael P. Lisanti

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 729)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Identification and Cellular Functions of Caveolae and Caveolins

    1. Front Matter
      Pages 1-1
    2. Valerie L. Reeves, Candice M. Thomas, Eric J. Smart
      Pages 3-13
    3. Cécile Boscher, Ivan Robert Nabi
      Pages 29-50
    4. Chieko Mineo, Philip W. Shaul
      Pages 51-62
  3. Caveolae and Caveolins in Human Diseases

    1. Front Matter
      Pages 63-63
    2. Fabiana S. Machado, Nilda E. Rodriguez, Daniel Adesse, Luciana R. Garzoni, Lisia Esper, Michael P. Lisanti et al.
      Pages 65-82
    3. Isabelle Mercier, Michael P. Lisanti
      Pages 83-94
    4. Michael R. Freeman, Wei Yang, Dolores Di Vizio
      Pages 95-110
    5. Stephanos Pavlides, Jorge L. Gutierrez-Pajares, Christiane Danilo, Michael P. Lisanti, Philippe G. Frank
      Pages 127-144
    6. Mathivadhani Panneerselvam, Hemal H. Patel, David M. Roth
      Pages 145-156
    7. Nikolaos A. Maniatis, Olga Chernaya, Vasily Shinin, Richard D. Minshall
      Pages 157-179
  4. Back Matter
    Pages 181-184

About this book


Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.


Caveolae Caveolin Frank Jasmin Lisanti Mechanism Signaling

Editors and affiliations

  • Jean-François Jasmin
    • 1
  • Philippe G. Frank
    • 2
  • Michael P. Lisanti
    • 2
  1. 1.Department of Stem Cell Biology and Regenerative MedicineThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Departments of Cancer Biology, and Stem Cell Biology and Regenerative MedicineThomas Jefferson UniversityPhiladelphiaUSA

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