Chronic Hepatitis C Virus

1. Anti-viral Therapy for Chronic HCV

   1. Antiviral Targets in HCV

      • B. Kronenberger, S. Zeuzem

      Pages 203-225

   2. Mutations and the Development of Anti-viral Resistance

      • Anna Maria Geretti, Geoff Dusheiko

      Pages 227-249

   3. Peginterferon, Ribavirin and Anti-viral Triple Therapy

      • Patrick Marcellin, Nathalie Boyer, Tarik Asselah

      Pages 251-260

   4. Treating Chronic HCV Without Interferon and/or Ribavirin

      • Edward J. Gane

      Pages 261-269

   5. Maintenance Therapy with Oral Antiviral Agents

      • Andrew Aronsohn, Donald Jensen

      Pages 271-277

2. Liver Transplantation for Chronic HCV

   1. Front Matter

      Pages 279-279

      PDF

   2. Natural History of Chronic HCV After Liver Transplantation

      • Bart J. Veldt, Michael R. Charlton

      Pages 281-290

   3. Use of HCV-Positive Organs in Patients With and Without Chronic HCV

      • Elizabeth C. Verna, Robert S. Brown Jr.

      Pages 291-300

   4. Treating HCV Prior to Liver Transplantation

      • Alvaro Martinez-Camacho, Brett E. Fortune, Gregory T. Everson

      Pages 301-312

   5. Treating HCV After Liver Transplantation

      • Michael Chang, Hubert Sung, Sammy Saab

      Pages 313-323

3. Back Matter

   Pages 325-332

   PDF

Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

• hepatology

From the reviews:

“This book is an important contribution to the field. … This well-written, concise, and current book will find a home on the shelves of many hepatologists and gastroenterologists. In addition, because it is so readable, it should be useful for students, GI/hepatology fellows, and midlevel providers dealing with patients and doing research. … This is a concise, updated, and well-written book that belongs in the libraries of healthcare providers and researchers in the field of HCV infection as well as medical institutions.” (Paul Angulo, Doody’s Review Service, November, 2012)

“Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future represents a timely new text that is focused on the natural history, treatment, and liver transplantation for chronic hepatitis C virus (HCV) infection. … an excellent background reference for MD and PhD students, trainees, and clinicians in understanding the scientific basis for current management of chronic HCV infection and highlighting key areas for future investigation. … is a welcome addition to any library and true to its name … .” (Richard Sterling and Joseph Lim, Gastroenterology, Vol. 143 (6), 2012)

• Bon Secours Health System, Liver Institute of Virginia, Newport News, USA

  Mitchell L. Shiffman

Mitchell L.  Shiffman, MD
Liver Institute of Virginia, Bon Secours Health System, Richmond, VA, USA

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