Biomaterials Associated Infection

Immunological Aspects and Antimicrobial Strategies

  • T. Fintan Moriarty
  • Sebastian A.J. Zaat
  • Henk J. Busscher

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The Pathogenesis of Medical Device-Associated Infection

    1. Front Matter
      Pages 1-1
    2. Werner Zimmerli, Andrej Trampuz
      Pages 3-24
    3. Dietrich Mack, Angharad P. Davies, Llinos G. Harris, Rose Jeeves, Ben Pascoe, Johannes K.-M. Knobloch et al.
      Pages 25-56
    4. Christine Heilmann, Friedrich Götz
      Pages 57-85
    5. Guruprakash Subbiahdoss, Joana F. da Silva Domingues, Roel Kuijer, Henny C. van der Mei, Henk J. Busscher
      Pages 107-117
    6. Sebastian A. J. Zaat
      Pages 175-207
    7. Oscar Murillo, Jaime Lora-Tamayo, Javier Ariza
      Pages 209-227
    8. Paul H. S. Kwakman, Sebastian A. J. Zaat
      Pages 229-248
    9. Georgios N. Belibasakis, Thomas Thurnheer, Nagihan Bostanci
      Pages 249-271
    10. Lorenzo Calabro, Cameron Lutton, Ahmed Fouad Seif El Din, R. Geoff Richards, T. Fintan Moriarty
      Pages 273-304
  3. Biomaterial-Based Strategies to Reduce Medical Device-Associated Infection

    1. Front Matter
      Pages 305-305
    2. Benjamin D. Brooks, Amanda E. Brooks, David W. Grainger
      Pages 307-354
    3. Neil Poulter, Krasimir Vasilev, Stefani S. Griesser, Hans J. Griesser
      Pages 355-378
    4. J. A. Loontjens
      Pages 379-404
    5. K. G. Neoh, Z. L. Shi, E. T. Kang
      Pages 405-432
  4. Clinical Applications, Case Studies

    1. Front Matter
      Pages 433-433
    2. Gerhard Schmidmaier, Abhay D. Gahukamble, T. Fintan Moriarty, R. Geoff Richards
      Pages 435-453
    3. Rabih O. Darouiche
      Pages 485-503
  5. Back Matter
    Pages 557-565

About this book


Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function.  These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.

Provides a clinical perspective to set research directions

Summarizes the pathogenicity of the most common bacterial species isolated in BAI
Covers both biofilms and tissue reservoirs as modes of infection
Presents state-of-the-art issues of immune function in the vicinity of implanted biomaterials
Describes the latest technologies for antimicrobial activation of biomaterials


Anti-adhesive and Antibacterial Polymer Brushes Anti-adhesive and Antibacterial  Polymer Brushes Anti-infective material Antibacterial biomaterials Antibiotic coating device Antibiotic release Antimicrobial biomaterials Antimicrobial coating device Antimicrobial device Antimicrobial-Modified Vascular Catheters BAI Biomaterial dendritic cell interactions Coagulase negative staphylococci infection Colonization of tissue surrounding inserted medical devices Dendritic cell-biomaterial interactions Implant associated infection Infection of inserted or implanted medical devices Intracellular bacteria Medical device associated infection Peri-implant tissue colonization Peri-implantitis biofilm Preventive Strategies in VAP Propionibacterium acnes Quaternary ammonium Compounds Rifampin biofilm S. epidermidis biofilm interactions S. epidermidis/ S. aureus biofilm Silver containing biomaterials Staphylococcal virulence factors Staphylococcus aureus Staphylococcus aureus implant associated infection Staphylococcus aureus infection of implanted medical devices Staphylococcus aureus medical device associated infection Staphylococcus epidermidis Staphylococcus epidermidis implant associated infection Staphylococcus epidermidis infection of inserted medical devices Staphylococcus epidermidis medical device associated infection biofilm formation biomaterial biomaterial antimicrobials biomaterial associated infection biomaterial implanted biomaterials immunology foreign body response immune function implanted biomaterial immune response implanted indwelling bladder catheter indwelling bladder catheter infection race for the surface tissue colonisation in BAI tissue infection

Editors and affiliations

  • T. Fintan Moriarty
    • 1
  • Sebastian A.J. Zaat
    • 2
  • Henk J. Busscher
    • 3
  1. 1.AO Research Institute DavosDavos PlatzSwitzerland
  2. 2., Medical MicrobiologyAcademic Medical CenterAmsterdamNetherlands
  3. 3.University Medical Center GroningenGroningenNetherlands

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