© 2012

Endocrine FGFs and Klothos

  • Makoto Kuro-o


  • Discusses potential of FGF23 and Klotho as novel diagnostic markers and therapeutic targets for chronic kidney disease

  • Gives an overview of current knowledge on FGF19 and FGF21

  • Comprehensive in scope


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 728)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Andrew Beenken, Moosa Mohammadi
    Pages 1-24
  3. Makoto Kuro-o
    Pages 25-40
  4. Clemens Bergwitz, Harald Jüppner
    Pages 41-64
  5. M. Shawkat Razzaque
    Pages 84-91
  6. Justin Silver, Tally Naveh-Many
    Pages 92-99
  7. Chou-Long Huang
    Pages 100-106
  8. Patricia Wahl, Myles Wolf
    Pages 107-125
  9. Ming Chang Hu, Makoto Kuro-o, Orson W. Moe
    Pages 126-157
  10. Takashi Shimada, Seiji Fukumoto
    Pages 158-170
  11. Stacey A. Jones
    Pages 171-182
  12. Benjamin C. Lin, Luc R. Desnoyers
    Pages 183-194
  13. Yang Zhao, James D. Dunbar, Alexei Kharitonenkov
    Pages 214-228
  14. Back Matter
    Pages 229-233

About this book


Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.


Endocrine FGF Fibroblast growth factor Klotho Kuro-o

Editors and affiliations

  • Makoto Kuro-o
    • 1
  1. 1.Department of PathologyUniversity of Texas Southwestern Medical Center at DallasDallasUSA

About the editors

MAKOTO KURO-O is an Associate Professor in the Pathology Department at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern). He also has an appointment to the Pak Center for Mineral Metabolism and the Simmons Comprehensive Cancer Center in UT Southwestern. He received his MD and PhD from the University of Tokyo, Japan. His major research interests include molecular mechanisms of aging and age-related diseases with special reference to chronic kidney disease. He is a member of the American Society of Nephrology (ASN).

Bibliographic information

  • Book Title Endocrine FGFs and Klothos
  • Editors Makoto Kuro-o
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4614-0886-4
  • eBook ISBN 978-1-4614-0887-1
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages XX, 210
  • Number of Illustrations 37 b/w illustrations, 1 illustrations in colour
  • Topics Cell Biology
    Gene Expression
  • Buy this book on publisher's site
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