© 2012

Neurodegenerative Diseases

  • Shamim I. Ahmad
  • Presents overviews of the current status of research and pointers to future research goals

  • Written by experts

  • Covers autism, Creutzfeldt-Jakob disease, epilepsy, frontotemporal lobar degeneration, multiple sclerosis, Down syndrome, premature ageing, and spinocerebellar ataxia and many more


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 724)

Table of contents

  1. Front Matter
    Pages i-xxxii
  2. Joy B. Parrish, E. Ann Yeh
    Pages 1-14
  3. Sam Khandhadia, Jocelyn Cherry, Andrew John Lotery
    Pages 15-36
  4. Thomas Westermaier, Tilmann Schweitzer, Ralf-Ingo Ernestus
    Pages 37-50
  5. Carmen Espinós, Eduardo Calpena, Dolores Martínez-Rubio, Vincenzo Lupo
    Pages 61-75
  6. Beata Sikorska, Richard Knight, James W. Ironside, Paweł P. Liberski
    Pages 76-90
  7. Kunio Miyake, Takae Hirasawa, Tsuyoshi Koide, Takeo Kubota
    Pages 91-98
  8. Tomonori Ono, Aristea S. Galanopoulou
    Pages 99-113
  9. Enrico Premi, Alessandro Padovani, Barbara Borroni
    Pages 114-127
  10. Paweł P. Liberski
    Pages 128-137
  11. Shiyao Wang
    Pages 138-142
  12. Paweł P. Liberski, Beata Sikorska, Paul Brown
    Pages 143-153
  13. Seth J. Perlman, Soe Mar
    Pages 154-171
  14. Sónia C. Correia, Renato X. Santos, George Perry, Xiongwei Zhu, Paula I. Moreira, Mark A. Smith
    Pages 205-221
  15. Elżbieta Miller
    Pages 222-238
  16. Hiroyuki Umegaki
    Pages 258-265

About this book


The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.


Ahmad Autism Creutzfeldt-Jakob disease Disease Epilepsy Multiple sclerosis Neurodegenerative

Editors and affiliations

  • Shamim I. Ahmad
    • 1
  1. 1.School of Science and TechnologyNottingham Trent UniversityNottinghamUK

About the editors

Shamim I. Ahmad after obtaining his Master’s degree in Botany from Patna University, Bihar, India and his PhD in Molecular Genetics from Leicester University, England, joined Nottingham Polytechnic as Grade 1 lecturer and was subsequently promoted to SL post. Nottingham Polytechnic subsequently became Nottingham Trent University where, after serving for about 37 years, he took early retirement to spend the remaining time writing books and conducting full‑time research. For more than three decades he worked on different areas of biology including thymineless death in bacteria, genetic control of nucleotide catabolism, development of anti‑AIDS drugs, control of microbial infection of burns, phages of thermophilic bacteria and microbial flora of Chernobyl after the nuclear accident. But his primary interest, which started 27 years ago, is DNA damage and repair, particularly near UV photolysis of biological compounds, production of reactive oxygen species and their implications on human health including skin cancer and xeroderma pigmentosum. He is also investigating photolysis of non‑biological compounds such as 8‑methoxypsoralen+UVA, mitomycin C, and nitrogen mustard and their importance in psoriasis treatment and in Fanconi anemia. In 2003 he received a prestigious “Asian Jewel Award” in Britain for “Excellence in Education”. He is also the Editor of Molecular Mechanisms of Fanconi Anaemia, Molecular Mechanisms of Xeroderma Pigmentosum, Molecular Mechanisms of Fanconi Anaemia, Molecular Mechanisms of Xeroderma Pigmentosum, Molecular Mechanisms of Ataxia Telangiectasia, Molecular Mechanisms of Cockayne Syndrome and Diseases of DNA Repair published by Landes Bioscience.

Bibliographic information

  • Book Title Neurodegenerative Diseases
  • Editors Shamim I. Ahmad
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4614-0652-5
  • eBook ISBN 978-1-4614-0653-2
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages XXXII, 390
  • Number of Illustrations 71 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
    Biomedicine, general
  • Buy this book on publisher's site
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