Cell Mechanics and Cellular Engineering

  • Van C. Mow
  • Roger Tran-Son-Tay
  • Farshid Guilak
  • Robert M. Hochmuth

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Constitutive Modeling and Mechanical Properties of Circulating Cells

    1. Front Matter
      Pages 1-1
    2. D. V. Zhelev, R. M. Hochmuth
      Pages 3-21
    3. R. Tran-Son-Tay, H. P. Ting-Beall, D. V. Zhelev, R. M. Hochmuth
      Pages 22-32
    4. R. E. Waugh, M. A. Tsai
      Pages 33-44
  3. Flow-Induced Effects on Cell Morphology and Function

    1. Front Matter
      Pages 53-53
    2. R. M. Nerem, P. R. Girard, G. Helmlinger, O. Thoumine, T. F. Wiesner, T. Ziegler
      Pages 55-69
    3. D. A. Jones, C. W. Smith, L. V. McIntire
      Pages 70-94
    4. H. Y. Shin, R. D. Iveson, F. A. Blumenstock, R. Bizios
      Pages 95-106
  4. Mechanics and Biology of Cell-Substrate Interactions

    1. Front Matter
      Pages 119-119
    2. D. A. Hammer, L. A. Tempelman, D. J. Goetz
      Pages 121-144
    3. A. Pierres, A. M. Benoliel, P. Bongrand
      Pages 145-159
    4. C. Zhu, T. E. Williams, J. Delobel, D. Xia, M. K. Offermann
      Pages 160-181
  5. Cell-Matrix Interactions and Adhesion Molecules

    1. Front Matter
      Pages 183-183
    2. A. J. Banes, M. Sanderson, S. Boitano, P. Hu, B. Brigman, M. Tsuzaki et al.
      Pages 210-232
  6. Molecular and Biophysical Mechanisms of Mechanical Signal Transduction

    1. Front Matter
      Pages 253-253
    2. A. Ben-Ze’ev, J. L. Rodríguez Fernández, B. Geiger, M. Zöller, U. Glück
      Pages 273-293
    3. S. R. P. Gudi, J. A. Frangos
      Pages 294-307
  7. Physical Regulation of Tissue Metabolic Activity

    1. Front Matter
      Pages 343-343
    2. V. C. Mow, N. M. Bachrach, L. A. Setton, F. Guilak
      Pages 345-379
    3. F. Guilak, H. J. Donahue, R. A. Zell, D. Grande, K. J. McLeod, C. T. Rubin
      Pages 380-397
    4. J. J. Parkkinen, M. J. Lammi, M. I. Tammi, H. J. Helminen
      Pages 420-444
  8. Mechanics of Cell Motility and Morphogenesis

    1. Front Matter
      Pages 457-457
    2. R. Skalak, B. A. Skierczynski, S. Usami, S. Chien
      Pages 459-478
    3. C. Dong, J. You, S. Aznavoorian, D. Savarese, L. A. Liotta
      Pages 515-533

About this book


Cell mechanics and cellular engineering may be defined as the application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological cells and the development of biological substitutes to restore cellular functions. This definition is derived from one developed for tissue engineering at a 1988 NSF workshop. The reader of this volume will see the definition being applied and stretched to study cell and tissue structure-function relationships. The best way to define a field is really to let the investigators describe their areas of study. Perhaps cell mechanics could be compartmentalized by remembering how some of the earliest thinkers wrote about the effects of mechanics on growth. As early as 1638, Galileo hypothesized that gravity and of living mechanical forces place limits on the growth and architecture organisms. It seems only fitting that Robert Hooke, who gave us Hooke's law of elasticity, also gave us the word "cell" in his 1665 text, Micrographid, to designate these elementary entities of life. Julius Wolffs 1899 treatise on the function and form of the trabecular architecture provided an incisive example of the relationship between the structure of the body and the mechanical load it bears. In 1917, D' Arcy Thompson's On Growth and Form revolutionized the analysis of biological processes by introducing cogent physical explanations of the relationships between the structure and function of cells and organisms.


DNA biochemistry biophysics cell cytoskeleton gene gene expression leukocytes metabolism migration morphogenesis morphology neutrophils regulation tissue

Editors and affiliations

  • Van C. Mow
    • 1
  • Roger Tran-Son-Tay
    • 2
  • Farshid Guilak
    • 3
  • Robert M. Hochmuth
    • 4
  1. 1.Orthopaedic Research LaboratoryColumbia UniversityNew YorkUSA
  2. 2.Department of Aerospace Engineering, Mechanics and Engineering ScienceUniversity of FloridaGainesvilleUSA
  3. 3.Musculo-Skeletal Research Laboratory, Department of Orthopaedics, Health Science CenterState University of New YorkStony BrookUSA
  4. 4.Department of Mechanical Engineering and Material SciencesDuke UniversityDurhamUSA

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