Corynebacterium Parvum

Applications in Experimental and Clinical Oncology

  • Bernard Halpern

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Bacteriology and Taxonomy

    1. Front Matter
      Pages 1-1
    2. M. Roumiantzeff, M. C. Mynard, B. Coquet, C. Goldman, G. Ayme
      Pages 11-27
    3. Back Matter
      Pages 28-31
  3. Toxicology, Pharmacology, Adjuvant Properties

    1. Front Matter
      Pages 33-33
    2. C. Adlam, D. E. Reid, P. Torkington
      Pages 35-39
    3. P. Jollès, D. Migliore-Samour, M. Korontzis, F. Floc’h, R. Maral, G. H. Werner
      Pages 40-47
    4. Back Matter
      Pages 66-73
  4. Corynebacterium parvum in Microbial Immunity

  5. Action of Corynebacterium on the Immune Cell System

    1. Front Matter
      Pages 105-105
    2. A. J. Treves, I. R. Cohen, M. Feldman
      Pages 107-111
    3. Bernard Halpern
      Pages 126-131
    4. Bernard Halpern
      Pages 145-147
    5. Bernard Halpern
      Pages 171-172
    6. Nikolai V. Dimitrov, Simonne Andre, George Eliopoulos, Bernard Halpern
      Pages 173-180
    7. Bernard Halpern
      Pages 187-188
  6. Corynebacterium parvum in Experimental Tumors and Metastasis

    1. Front Matter
      Pages 189-189
    2. Bernard Halpern
      Pages 200-201
    3. M. Roumiantzeff, M. Musetescu, G. Ayme, M. C. Mynard
      Pages 202-217
    4. Bernard Fisher, Norman Wolmark, E. R. Fisher
      Pages 218-243
    5. J. E. Castro, T. E. Sadler
      Pages 252-263
    6. Bernard Halpern
      Pages 264-267
    7. Nikolai V. Dimitrov, Ivan Chouroulinkov, Lucien Israel, John J. O’Rangers
      Pages 276-283
    8. Lukas Milas, Nancy Hunter, Ivan Bašić, Kathy Mason, H. Rodney Withers
      Pages 284-296
    9. Bernard Halpern
      Pages 297-297
    10. Bernard Halpern
      Pages 319-326
  7. Corynebacterium parvum in Human Tumors

    1. Front Matter
      Pages 327-327
    2. Richard C. Reed, Jordan U. Gutterman, Giora M. Mavligit, Andrew A. Burgess, Evan M. Hersh
      Pages 349-366
    3. Bernard Halpern
      Pages 367-371

About this book


In his introduction to the Ciba Foundation Symposium on "Immunopotentia­ tion," Sir Peter Medawar stated that, "for the past twenty years the control of the immune response has been virtually equated to immunosuppression because the great goal of applied immunology has been the transplantation of tissues," and that, "with the discovery of tumor immunity-the focal point of immuno­ logical control has changed from immunosuppression to immunpotentiation and correspondingly the great prize of applied immunology has become the preven­ tion and control of malignant growth." Corynebacterium parvum is now univer­ sally recognized as being the most potent presently known immunopotentiator. C parvum is at the center of almost all papers presented at this conference and it has been analyzed from various viewpoints: taxonomy, pharmacology, immunopotentiation, stimulation of host resistance to tumor invasion in experi­ mental models and in human therapeutics. Almost all data reported in this volume are original and recently obtained. The discussions were spontaneous, stimulating, and highly enriching, and the results already established and re­ ported here are in many respects unique. Discussions at the conference revealed many other aspects which require further exploration. Nonspecific immunopotentiation has strongly penetrated into immunology, immunopathology, and, recently, oncology. Undoubtedly, this area of research will witness important developments in the near future. This book offers the first synthesis of presently available knowledge and emphasizes future prospects.


oncology pathology pharmacology transplantation tumor

Editors and affiliations

  • Bernard Halpern
    • 1
  1. 1.Collège de FranceFrance

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