Kidney in Essential Hypertension

Proceedings of the Course on the Kidney in Essential Hypertension held at New Orleans, Louisiana, March 18–19, 1983

  • Franz H. Messerli

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 35)

Table of contents

  1. Front Matter
    Pages i-xii
  2. The Kidney in the Pathogenesis of Essential Hypertension

    1. Nick C. Trippodo
      Pages 15-23
    2. John C. McGiff
      Pages 43-54
    3. Harry S. Margolius, Julie Chao, Alan W. Cuthbert
      Pages 55-64
    4. John E. Hall, Arthur C. Guyton, Joey P. Granger, Thomas G. Coleman
      Pages 87-103
  3. The Kidney as a Target Organ in Essential Hypertension

    1. Friedrich C. Luft, M. H. Weinberger
      Pages 105-123
    2. Efrain Reisin, Franz H. Messerli, Hector O. Ventura, Edward D. Frohlich
      Pages 125-129
    3. E. D. Frohlich, F. H. Messerli, F. G. Dunn
      Pages 149-156
  4. Antihypertensive Treatment and the Kidney

About this book


The kidney, similar to the heart, plays a three-fold role in essential hypertension. First, it participates in the patho­ genesis of arterial hypertension. Second, it suffers as a target organ of long-standing hypertension, and third, it experiences the effects of antihypertensive therapy. Perhaps most contested at the present time is the involvement of the kidney in the patho­ genesis of essential hypertension. More than a century ago, William Osler put forward three basic hypotheses about the "genuine contracted kidney. "l 1. "The hypertrophy can be regarded as an effect to overcome a sort of stop-cock action of the vessels when under the influence of an irritating ingredient in the blood greatly contracted and increased the peripheral resistance. " Clearly this hypothesis of an "irritating ingredient" is perhaps the most convincing nowadays, and numerous attempts have been made to identify a specific vasoconstrictive agent in the blood in essential hypertension. 2. "The obliteration of a large number of capillary territories in the kidney materially raised the arterial pressure. An additional factor of dimin­ ished excretion of water also heightened the pressure within the blood vessel. " Today we know that fluid volume overload in the presence of reduced renal mass seems to be the most likely mechanism accoun­ ting for renal parenchymal hypertension and, as shown by Guyton's group, for certain forms of experimental hypertension. 3.


arterial pressure cardiovascular cardiovascular regulation heart hemodynamics hypertension kidney

Editors and affiliations

  • Franz H. Messerli
    • 1
    • 2
  1. 1.Hemodynamic LaboratoryOchsner Clinic and Alton Ochsner Medical FoundationNew OrleansUSA
  2. 2.Tulane University School of MedicineNew OrleansUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1984
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-3899-4
  • Online ISBN 978-1-4613-3897-0
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site
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