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Comparative Chemical Mutagenesis

  • Frederick J. De Serres
  • Michael D. Shelby

Table of contents

  1. Front Matter
    Pages i-viii
  2. Introduction

    1. Frederick J. de Serres
      Pages 1-4
  3. Analysis of Genetic Effects by Test System

    1. H. E. Brockman, C. Y. Hung, F. J. de Serres, T. M. Ong
      Pages 109-138
    2. E. Vogel, A. Schalet, W. R. Lee, F. Würgler
      Pages 175-255
    3. R. A. Nilan, J. Velemínský
      Pages 291-320
    4. J. Velemínský, T. Gichner
      Pages 321-327
    5. R. Rieger, A. Michaelis, I. Schubert, B. Kaina, K. Heindorff
      Pages 339-351
    6. R. Braun, J. Schöneich, M. S. Legator, D. B. McGregor, G. R. Mohn
      Pages 353-392
    7. D. Clive, K. O. Johnson, A. G. Batson, J. F. S. Spector
      Pages 393-431
    8. J. G. Brewen, A. T. Natarajan, G. Obe
      Pages 433-485
    9. B. J. Dean, D. Anderson, R. J. Šrám
      Pages 487-538
    10. S. Wolff, P. Perry, A. T. Natarajan
      Pages 539-547
    11. R. J. Preston, I.-D. Adler, A. Léonard, M. F. Lyon
      Pages 549-631
    12. W. M. Generoso, B. Cattanach, A. M. Malashenko
      Pages 681-707
    13. R. Fahrig, G. W. P. Dawson, L. B. Russell
      Pages 709-727
  4. Analysis of Genetic Effects by Test Chemical

  5. Risk Estimation

  6. Back Matter
    Pages 1103-1117

About this book

Introduction

Frederick J. de Serres, Ph. D. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga­ nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. In the past, data on chemical mutagens has been generated and published in the scientific literature on a more or less random basis. Individual chemicals enjoy a brief period of "popularity" that leads to a burst of publications in the same or sometimes related assay systems. The incompleteness of the data base, in many of these cases, makes comparative mutagenesis difficult or impossible. In our attempts to compare the genetic effects of a given chemical over a wide range of assay systems, we are often interested in making quantitative as well as qualitative compari­ sons. To restate the first comparison: is the chemical under ques­ tion a weak, moderate or potent mutagen over a wide range of assay systems--or alternatively, does the level of response vary markedly? To make the second comparison, what is needed is information on the spectrum of genetic alterations produced as well as whether this spectrum is consistent over a wide range of organisms.

Keywords

DNA DNA repair Drosophila Vivo cadmium environment genes genetics information iron mutation population recombination solution soybean

Editors and affiliations

  • Frederick J. De Serres
    • 1
  • Michael D. Shelby
    • 1
  1. 1.National Institute of Environmental Health SciencesUSA

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