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Monoclonal Antibodies and Breast Cancer

Proceedings of the International Workshop on Monoclonal Antibodies and Breast Cancer San Francisco, California — November 8–9, 1984

  • Roberto L. Ceriani
Book

Part of the Developments in Oncology book series (DION, volume 35)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Session I

    1. Front Matter
      Pages 1-1
    2. F. Hendler, W. Kingsley, D. Burns, D. House, K. Patrick, D. Yuan
      Pages 13-27
    3. J. Hilkens, V. Kroezen, F. Buijs, J. Hilgers, M. van Vliet, W. de Voogd et al.
      Pages 28-42
    4. Renato Dulbecco, W. Ross Allen, Christine White
      Pages 43-59
    5. J. Taylor-Papadimitriou, J. Bartek, E. Durban, J. Burchell, R. C. Hallowes, E. B. Lane et al.
      Pages 60-79
    6. C. F. Lemaistre, D. P. Edwards, L. G. Dressler, B. Lathan, R. E. Mansel, W. L. McGuire
      Pages 80-85
  3. Session II

    1. Front Matter
      Pages 87-87
    2. R. J. Cote, D. Morrissey, A. N. Houghton, T. M. Thomson, C. Cordon-Cardo, H. F. Oettgen et al.
      Pages 89-107
    3. P. Horan Hand, M. O. Weeks, J. Greiner, A. Thor, D. Colcher, C. Szpak et al.
      Pages 108-118
    4. Z. Steplewski, M. Blaszczyk, D. Herlyn, M. Herlyn, H. Koprowski
      Pages 134-149
  4. Session III

    1. Front Matter
      Pages 151-151
    2. M. I. Colnaghi, S. Canevari, G. Della Torre, R. Mariani-Costantini, S. Menard, S. Miotti et al.
      Pages 153-164
    3. R. Chan, P. V. Rossitto, B. F. Edwards, R. D. Cardiff
      Pages 165-178
    4. K. G. Burnett, E. Oh, J. Hayden
      Pages 179-189
    5. K. McCarty Jr., J. Snowhite, E. Cox, L. Miller, K. McCarty Sr.
      Pages 190-202
  5. Session IV

    1. Front Matter
      Pages 203-203
    2. J. N. Weinstein, A. M. Keenan, O. D. Holton III, D. G. Covell, S. M. Sieber, C. D. V. Black et al.
      Pages 218-232
    3. S. Stacker, M. G. Lowe, K. McKatee, C. H. Thompson, M. Lichtenstein, M. Leyden et al.
      Pages 233-247
    4. A. Frankel, D. Ring, M. Bjorn, W. Bloch, W. Laird, K. T. Chong et al.
      Pages 269-292
    5. Lawrence D. Papsidero, Gary A. Croghan, Patrick M. Capone, Edward A. Johnson
      Pages 293-302

About this book

Introduction

Breast cancer, being a disease with very high prevalence in the female population, has permanently attracted the attention of biologists, biochemists, pathologists, surgeons, and oncologists. In the U.S. alone approximately 120,000 new cases are diagnosed and 37,000 deaths a year are recorded as an outcome. Early diagnosis, clear cut prognosis and the hope of new therapeutic approaches has spurred the enthusiasm of researchers, who with the advent of newer methodologies, tried to employ it in different approaches to the breast cancer patient. In spite of the efforts devoted towards the creation of new approaches, reagents and procedures taking advantage of special characteristics of the breast tissue were slow to come. In general, most diagnostic and prognostic techniques were those shared and applied to other carcinomas. In the early seventies we discovered the first sets of antigens associated with breast epithelial tissue both in the mouse and the human. The recognition of such group of molecules, present in the milk fat globule membrane, gave impetus to several studies in these areas. These mammary cell surface antigens proved useful in several diagnostic approaches such as radioimaging, histochemical and serum assay procedures. However, the apparently inherent limitations of polyclonal antibodies reduced the impact of these novel approaches.

Keywords

Antigen carcinoma cell imaging metastasis proteins tumor

Editors and affiliations

  • Roberto L. Ceriani
    • 1
  1. 1.John Muir Cancer and Aging Research InsituteWalnut CreekUSA

Bibliographic information

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Pharma
Health & Hospitals
Biotechnology
Oncology & Hematology