Clinical Investigation of the Microcirculation

Proceedings of the Meeting on Clinical Investigation of the Microcirculation held at London, England September, 1985

  • John E. Tooke
  • L. H. Smaje

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 59)

Table of contents

  1. Front Matter
    Pages i-ix
  2. The Direct Techniques

    1. Front Matter
      Pages 1-1
    2. John E. Tooke
      Pages 3-22
    3. Bengt Fagrell, Jan Östergren
      Pages 23-33
  3. Indirect Methodologies

  4. Clinical Applications

    1. Front Matter
      Pages 127-127
    2. S. A. Williams, J. E. Tooke
      Pages 129-143
    3. U. K. Franzeck, K. A. Jäger, A. Bollinge
      Pages 145-155
    4. Jan Östergren, Bengt Fagrell
      Pages 157-167
    5. J. O. Roberts, B. M. Jones
      Pages 199-224

About this book


In 1628 William Harvey published his discovery of the existence of the microcirculation which he deduced from careful anatomical and physiological study. Thirty-three years later, Malpighi confirmed the presence of capillaries through direct microscopical observation. Subsequent scientific advance has been slow, and in view of the fact that microvascular in the genesis and expression of many pathophysiology may be implicated diseases, our know ledge of human microvascular function is surprisingly limited. This ignorance attests to the difficulty of studying something that is both minute and inaccessible without disturbing the quantity that is being measured. In the last fifteen years, however, direct techniques have been developed for studying human microvascular pressure, flow and permeability. These methods have provided new insights into human microvascular function in health and disease. At the same time there has been a steady growth of new indirect techniques based on a w ide range of physical principles that reflect some or other aspect of microvascular function.


blood circulation hypertension physiology

Editors and affiliations

  • John E. Tooke
    • 1
  • L. H. Smaje
    • 1
  1. 1.Charing Cross and Westminster Medical SchoolUniversity of LondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1987
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9434-4
  • Online ISBN 978-1-4613-2335-8
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site
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