Immunobiology and Immunopharmacology of Bacterial Endotoxins

  • Andor Szentivanyi
  • Herman Friedman
  • Alois Nowotny

Table of contents

  1. Front Matter
    Pages i-x
  2. Introductory Section

  3. Chemical and Molecular Characteristics of Endotoxins

  4. Physiological and Pharmacological Effects of Endotoxins

    1. Front Matter
      Pages 97-97
    2. John J. Spitzer, Gregory J. Bagby, Charles H. Lang
      Pages 99-110
    3. Michael R. Yelich, Linda Witek-Janusek, James P. Filkins
      Pages 111-132
    4. Joseph F. Williams, Andor Szentivanyi
      Pages 159-169
    5. Raymond E. Shepherd, Charles H. Lang, Brent A. Brumfield, Norman W. Robie, Karen R. DuSapin, Kathleen H. McDonough
      Pages 171-185
    6. John W. Hadden, Ann Galy, Elba M. Hadden, J. L. Touraine, Ronald G. Coffey
      Pages 187-198
  5. Immunogenicity and Non-Specific Effects of Endotoxin

    1. Front Matter
      Pages 199-199
    2. L. Chedid, M. Parant, F. Parant, G. Riveau
      Pages 201-213
    3. A. C. Rodloff, P. Gädke, F. Lux, H. Hahn
      Pages 215-219
    4. Renate Urbaschek, Daniela N. Männel, Stephan E. Mergenhagen, Bernhard Urbaschek
      Pages 221-231
    5. Toby K. Eisenstein, Loran M. Killar, Barnet M. Sultzer, Marshall Phillips
      Pages 239-255
    6. B. W. Fenwick, J. S. Cullor, A. Kelly
      Pages 257-263
    7. J. S. Cullor, B. Fenwick, B. P. Smith, K. Pelzer, A. Kelly, B. I. Osburn
      Pages 265-268
    8. Joseph G. Sinkovics
      Pages 269-279
    9. Samuel B. Salvin, Pamela B. Renda
      Pages 291-297
  6. Effects of Endotoxins on Cells of the Immune System

    1. Front Matter
      Pages 299-299
    2. D. C. Morrison, H-W. Wollenweber, S. W. Vukajlovich, S. A. Goodman
      Pages 315-327
    3. Suzanne M. Michalek, Jerry R. McGhee, Dawn E. Colwell, Shane I. Williamson, Thomas A. Brown, David M. Spalding et al.
      Pages 329-338
    4. D. K. Blanchard, T. W. Klein, H. Friedman, W. E. Stewart II
      Pages 353-358
    5. R. Christopher Butler, Jeri M. Frier, Mrunal S. Chapekar, Herman Friedman, Alois Nowotny
      Pages 369-379
  7. Modulation of the Immune Response by Endotoxins

    1. Front Matter
      Pages 405-405
    2. Edgar Ribi, John L. Cantrell, Kuni Takayama, Hans O. Ribi, Kent R. Myers, Nilofer Qureshi
      Pages 407-420
    3. Kathryn Nixdorff, Sigrid Schell
      Pages 421-433
    4. Barnet M. Sultzer, John P. Craig, Raymond Castagna
      Pages 435-447
    5. Stephen A. Stimpson, Ronald E. Esser, William J. Cromartie, John H. Schwab
      Pages 449-454
    6. G. Pulverer, W. Roszkowski, H. L. Ko, K. Roszkowski, J. Jeljaszewicz
      Pages 455-458
    7. K. Roszkowski, H. L. Ko, D. van der Waaij, W. Roszkowski, J. Jeljaszewicz, G. Pulverer
      Pages 459-463
    8. Mauro Bendinelli, Donatella Matteucci, Anna Maria Giangregorio, Pier Giulio Conaldi
      Pages 465-478

About this book


Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le. , bacterial endo­ toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.


Antigen antibiotics bacteria immunobiology infection infections interferon leukemia lymphocytes macrophages pharmacology proteins research retroviruses virus

Editors and affiliations

  • Andor Szentivanyi
    • 1
  • Herman Friedman
    • 1
  • Alois Nowotny
    • 2
  1. 1.University of South Florida College of MedicineTampaUSA
  2. 2.University of PennsylvaniaPhiladelphiaUSA

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