The Cytoskeleton

A Target for Toxic Agents

  • Thomas W. Clarkson
  • Polly R. Sager
  • Tore L. M. Syversen

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Overview

    1. Polly R. Sager, Tore L. M. Syversen, Thomas W. Clarkson, John B. Cavanagh, Arnljot Elgsaeter, Hans Cato Guldberg et al.
      Pages 3-21
    2. Tore L. M. Syversen, Polly R. Sager, Thomas W. Clarkson, John B. Cavanagh, Anljot Elgsaeter, Hans Cato Guldberg et al.
      Pages 25-34
  3. Invited Papers

    1. Microtubules and Microtubule Inhibitors

    2. Cytoskeleton of the Nervous System

      1. Bruce G. Gold, John W. Griffin, Donald L. Price, Paul N. Hoffman
        Pages 119-127
      2. Pierluigi Gambetti, Salvatore Monaco, Lucila Autilio-Gambetti, Lawrence M. Sayre
        Pages 129-142
      3. Michael L. Shelanski
        Pages 159-166
      4. Doyle G. Graham, Gyöngyi Szakàl-Quin, Leslie Milam, Marcia R. Gottfried, D. Carter Anthony
        Pages 167-174
    3. Cytoskeleton and Membrane Related Events

      1. Hermann Passow, Melanie Shields, Paul La Celle, Ryszard Grygorczyk, Wolfgang Schwarz, Reiner Peters
        Pages 177-186
      2. Arnljot Elgsaeter, Arne Mikkelsen, Bjørn T. Stokke
        Pages 187-197
      3. Robin Jones, Michael Sheetz
        Pages 213-220
      4. Arnold R. Brody, Lila H. Hill, Thomas W. Hesterberg, J. Carl Barrett, Kenneth B. Adler
        Pages 221-227
      5. Patricia M. Hinkle, Jane Halpern, Patricia A. Kinsella, Risa A. Freedman
        Pages 229-242
  4. Conference Summary

    1. N. Karle Mottet
      Pages 243-251
  5. Perspectives

    1. Tore L. M. Syversen, Polly R. Sager, Thomas W. Clarkson
      Pages 253-254
  6. Back Matter
    Pages 255-261

About this book


This book is based on reviews and research presentations given at the 16th Rochester International Conference on Environmental Toxicity, entitled liThe Cytoskeleton: A Target for Toxic Agents," held on June 4, 5 and 6 in 1984. The conference provided an in-depth discussion of the effects a~d mechanism of action of some toxic agents on the cytoskeleton. Mamma"lian and other eukaryotic cells contain protein networks within the cytoplasm comprised of microfilaments, intermediate Hlaments and microtubules. These components of the cytoskeleton playa key role in cell shape, motility, intracellular organization and transport, and cell division. Furthermore, the cytoskeleton, via associations with the cell membrane, appears to function in intracellular communication and cellular responses to membrane events. Because of the complex functional roles of the cytoskeleton which vary with cell type, degree of differentiation, and cell cycle, its disruption may result in a variety of cellular changes. This expanding field in cell biology has already attracted the interest of toxicologists and environmental health scientists as a potentially fruitful area of research. Indeed, there is mounting evidence that certain toxic and chemotherapeutic compounds, as well as physical agents such as radiation and hydrostatic pressure, disrupt the normal structure and function of the cytoskeleton. This may be an important step in the overall expression of their action. It was, therefore, an opportune time to hold a conference to encourage the development of this area of toxicology and to suggest directions for future research.


Calcium Pathogene cell biology drug environment health mercury pesticide pesticides research toxicity toxicology toxin transport

Editors and affiliations

  • Thomas W. Clarkson
    • 1
  • Polly R. Sager
    • 2
  • Tore L. M. Syversen
    • 3
  1. 1.University of Rochester School of MedicineRochesterUSA
  2. 2.University of Connecticut Health CenterFarmingtonUSA
  3. 3.University of Trondheim Faculty of MedicineTrondheimNorway

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