Mechanisms of Receptor Regulation

  • George Poste
  • Stanley T. Crooke

Part of the New Horizons in Therapeutics book series (NHTH)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Leonard Jarett, Robert M. Smith
    Pages 1-11
  3. Joseph Schlessinger, Irit Lax, Shoshana Gill, Richard Kris, Towia A. Libermann, Menashe Bar-Eli et al.
    Pages 37-51
  4. Lilli M. Petruzzelli, Laurel Stadtmauer, Roman Herrera, Mary Makowske, Sabyasachi Ganguly, Diane Tabarini et al.
    Pages 53-64
  5. Martin Rodbell
    Pages 65-73
  6. W. H. Moolenaar, S. W. de Laat
    Pages 131-147
  7. Alfred G. Gilman, Murray D. Smigel, Gary M. Bokoch, Janet D. Robishaw
    Pages 149-158
  8. Edwin G. Krebs, Donald K. Blumenthal, Arthur M. Edelman, C. Nicholas Hales
    Pages 159-195
  9. Zanvil A. Cohn, Ralph M. Steinman
    Pages 197-206
  10. Aaron Ciechanover, Alan L. Schwartz, Harvey L. Lodish
    Pages 225-253
  11. Michael A. Raftery, Bianca M. Conti-Tronconi, Susan M. J. Dunn, Rebecca D. Crawford, David Middlemas
    Pages 255-278
  12. Berta Strulovici, Jeffrey M. Stadel, Robert J. Lefkowitz
    Pages 279-294
  13. Morley D. Hollenberg, H. Joseph Goren
    Pages 323-373
  14. Hans Schreiber, Carter van Waes, Hans Josef Stauss
    Pages 375-394
  15. Michael P. Czech, Roger J. Davis, Jeffrey E. Pessin, Cristina Mottola, Yoshitomo Oka
    Pages 395-415
  16. Back Matter
    Pages 417-432

About this book


It is less than 80 years since John Newport Langley first proposed the role of "receptive substances" as the site of drug action from his obser­ vations on the effects of nicotine and curare at the myoneural junction. The many advances in our understanding of receptor biology that have occurred during the intervening period mirror the extraordinary growth of knowledge in the biological sciences and in cell and molecular biology in particular. Receptor biology, in common with many other topics in contemporary biology, is on the threshold of a transition from being a descriptive, phenomenological discipline to one in which underlying mechanisms and regulatory principles can be defined with increasing pre­ cision. This change, together with the evolution of powerful analytical techniques and timely convergence of ideas from a number of previously separate fields of inquiry, is generating an increasingly unified theoretical and experimental framework for the study of receptor function. These themes, and the mood of anticipation that a real understanding of receptor function in health and disease is emerging, are reflected in in this volume, which summarizes the proceedings of the Sec­ the papers ond Smith Kline & French Research Symposium on New Horizons in Therapeutics held in Philadelphia in 1984.


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Editors and affiliations

  • George Poste
    • 1
  • Stanley T. Crooke
    • 1
  1. 1.Smith Kline and French LaboratoriesPhiladelphiaUSA

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