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Myocardial Ischemia

Proceedings of a Satellite Symposium of the Thirtieth International Physiological Congress July 8–11, 1986, Winnipeg, Canada

  • Naranjan S. Dhalla
  • Ian R. Innes
  • Robert E. Beamish

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 67)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Myocardial Cell Damage and Arrhythmias

  3. Pathophysiologic Aspects of Ischemic Injury

    1. Front Matter
      Pages 65-65
    2. R. Ferrari, C. Ceconi, S. Curello, A. Cargnoni, A. Albertini, E. O. Visioli
      Pages 67-84
    3. K. J. Kako, M. Kato
      Pages 99-112
    4. W. B. Weglicki, I. T. Mak, B. F. Dickens, J. H. Kramer
      Pages 113-122
    5. W. Kübler, R. Dietz, W. Mäurer, A. Schömig
      Pages 133-143
    6. R. M. Berne, J. M. Gidday, H. E. Hill, R. Rubio
      Pages 145-148
    7. Dennis B. McNamara, John A. Bellan, Philip R. Mayeux, Morris D. Kerstein, Albert L. Hyman, Philip J. Kadowitz et al.
      Pages 163-170
    8. N. Sreeharan, R. Jayakody, M. Senaratne, A. Thomson, T. Kappagoda
      Pages 171-182
  4. Metabolic Aspects of Cell Damage

  5. Calcium Antagonists and Myocardial Ischemia

    1. Front Matter
      Pages 283-283
    2. W. G. Nayler, W. J. Sturrock, S. Panagiotopoulos
      Pages 285-296
    3. J. M. J. Lamers, C. E. Essed, J. A. Post, A. J. Verkleij, F. J. ten Cate, W. J. Van der Giessen et al.
      Pages 297-310
    4. Philip R. Mayeux, Krishna C. Agrawal, Jen-Sie H. Tou, Barry T. King, Albert L. Hyman, Philip J. Kadowitz et al.
      Pages 339-353

About this book

Introduction

Whenever the coronary flow is inadequate to provide enough oxygen to meet the energy demands of the tissue, the heart becomes ischemic. Manifestations of myocardial ischemia include depression in contractile activity, changes in metabolic pattern, abnormalities in ultrastructure, and alterations in membrane potential. Ischemic changes during the early phase are reversible but as the period of ischemia is extended, the injury becomes irreversible. The transition from reversible to irreversible ischemic injury is usually associated with some membrane defects. It is worthwhile to consider that the irreversible damage to the ischemic myocardium occurs when the sarcolemmal membrane is altered in suoh a way that it would promote 2 a net gain of ca + in the cardiac cell upon reinstitution of blood flow. Suoh a lesion could result when mechanisms for the entry as well as removal 2 of ca + from the myocardial oell become defective. In this regard, 2 depression of the sarcolemmal ca + pump would favour the oocurrenoe of 2 intracellular ca + overload. Furthermore, inhibition of the Na+-K+ pump would lead to elevation of myoplasmic Na+ which oould then increase the 2 2 intracellular concentration of ca + through the sarcolemmal Na+-ca + exchange mechanism. In faot recent studies have revealed an inhibition of 2 the sarcolemmal Na+-ca + exchange mechanism in the ischemic heart and this 2 change could also contribute towards the occurrence of intracellular ca + 2 overload.

Keywords

arrhythmia artery atherosclerosis blood cardiovascular cell depression drugs energy heart heart disease myocardial infarction platelet thromboxane tissue

Editors and affiliations

  • Naranjan S. Dhalla
    • 1
  • Ian R. Innes
    • 1
  • Robert E. Beamish
    • 1
  1. 1.Youville Research Institute, St. Boniface General Hospital, and Faculty of MedicineUniversity of ManitobaWinnipegCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-2055-5
  • Copyright Information Springer-Verlag US 1987
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9221-0
  • Online ISBN 978-1-4613-2055-5
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site
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