Evolution of Longevity in Animals

A Comparative Approach

  • Avril D. Woodhead
  • Keith H. Thompson

Table of contents

  1. Front Matter
    Pages i-x
  2. Genetic and Environmental Determinants of Longevity in Drosophila

  3. Informational Structure of the Developmental Tree of Multi-Cellular Organisms

  4. Genetic and Environmental Manipulation of Aging in Caenorhabditis elegans

    1. Richard L. Russell, Renée I. Seppa
      Pages 35-48
  5. Scaling of Maximal Lifespan in Mammals: A Review

    1. John Prothero, Klaus D. Jürgens
      Pages 49-74
  6. Why Should Senescence Evolve? An Answer Based on a Simple Demographic Model

  7. Mutant Genes That Extend Life Span

    1. Thomas E. Johnson, David B. Friedman, Paul A. Fitzpatrick, William L. Conley
      Pages 91-100
  8. Longevity in the Protozoa

    1. Joan Smith-Sonneborn
      Pages 101-109
  9. The Heredity-Environment Continuum: A Systems Analysis

    1. Barbara E. Wright, Margaret H. Butler
      Pages 111-122
  10. The Proximate and Ultimate Control of Aging in Drosophila and Humans

    1. Alan R. Templeton, J. Spencer Johnston, Charles F. Sing
      Pages 123-133
  11. The Many Genetics of Aging

    1. Gerald E. McClearn
      Pages 135-144
  12. Lifespan Environmental Influences on Species Typical Behavior of Meriones Unguiculatus

  13. Longevity in Fish: Some Ecological and Evolutionary Considerations

  14. Evolutionary Reliability Theory

    1. Arnold R. Miller
      Pages 187-192
  15. Programmed Cell Death and Aging in Drosophila Melanogaster

  16. Immortality of the Germ-Line versus Disposability of the Soma

  17. Systems Ecology, Operations Research and Gerontology: The Making of Strange Bedfellows

  18. Demographic Consequences of Natural Selection

    1. George C. Williams, Peter D. Taylor
      Pages 235-245
  19. The Relationship of Body Weight to Longevity within Laboratory Rodent Species

  20. Is Cellular Senescence Genetically Programmed?

    1. James R. Smith, Andrea L. Spiering, Olivia M. Pereira-Smith
      Pages 283-294
  21. Information Content of Biological Survival Curves Arising in Aging Experiments: Some Further Thoughts

  22. Symposium Debate

    1. Richard L. Sprott, C. Ladd Prosser, Ronald W. Hart
      Pages 319-330
  23. Round Table Discussion

    1. Bentley Glass
      Pages 331-333
    2. Rajindar S. Sohal
      Pages 335-337
  24. Back Matter
    Pages 345-354

About this book


The analysis of intra-group correlations between LS and BW at representative intervals yields no consistent support for the hypothesis that lower BW is associated with longer LS. Indeed, among male Wistar rats and C57BL/6J and A/J mice followed since weaning on AL diets, the data suggested that relatively higher BW across the adult LS was generally associated with longer life. Even when the diet was restricted by EOD or RES regimens, this pattern of positive correlations between LS and BW persisted for the C57BL/6J and A/J strains when relative ages were analyzed. However, when BW at absolute ages were correlated with LS, support for the positive relationship between BW and LS was not as forthcoming. When AL groups were assessed beginning at later ages (> 10 months), the pattern of positive correlations was very evident for the Wistar rats--heavier rats tended to liver longer. This pattern was also evident among AL-fed C57BL/6J mice followed since 6 months, but was lost in the 10-month group in this strain. Among A/J mice on AL diets, the pattern became somewhat negative when followed at 6 and 10 months of age. However, among both C57BL/6J and A/J mice placed on EOD diets at 6 and 10 months of age, the pattern clearly tended toward the positive.


age aging evolution gerontology liver senescence

Editors and affiliations

  • Avril D. Woodhead
    • 1
  • Keith H. Thompson
    • 1
  1. 1.Biology Dept.Brookhaven National LaboratoryUptonUSA

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