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Development and Recognition of the Transformed Cell

  • Mark I. Greene
  • Toshiyuki Hamaoka

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Peter C. Nowell, Carlo M. Croce
    Pages 1-19
  3. Erica M. S. Sibinga, Gail R. Massey, Mark I. Greene
    Pages 59-67
  4. Tadashi Yamamoto, Kumao Toyoshima
    Pages 93-110
  5. Wendelyn H. Inman, Graham Carpenter
    Pages 111-121
  6. Naomi Rosenberg
    Pages 123-144
  7. Marie L. Dell’Aquila, Barbour S. Warren, David J. De Vries, Peter M. Blumberg
    Pages 157-185
  8. Mitsuaki Yoshida, Motoharu Seiki, Junichi Fujisawa, Junichiro Inoue
    Pages 187-202
  9. Satvir S. Tevethia, Janet S. Butel
    Pages 231-242
  10. Paul W. Johnson, William S. Trimble, Nobumichi Hozumi, John C. Roder, Anthony J. Pawson
    Pages 243-259
  11. Katsuo Kumagai, Ryuji Suzuki, Satsuki Suzuki, Tetsu Takahashi, Minoru Igarashi
    Pages 261-277
  12. J. Kevin Steele, Agnes Chan, Anthea T. Stammers, Julia G. Levy, Rakesh Singhai
    Pages 279-293
  13. Robert J. North, Antonio DiGiacomo, Earl S. Dye
    Pages 295-305
  14. Hiromi Fujiwara, Takayuki Yoshioka, Hiroto Nakajima, Masahiro Fukuzawa, Kohichi Sakamoto, Masato Ogata et al.
    Pages 331-354
  15. Toshiyuki Hamaoka, Yasuyuki Takai, Atsushi Kosugi, Junko Shima, Takashi Suda, Yumiko Mizushima et al.
    Pages 355-372
  16. Alan N. Houghton, Laura J. Davis, Nicolas C. Dracopoli, Anthony P. Albino
    Pages 373-383
  17. Philip D. Greenberg, Donald E. Kern, Michael C. V. Jensen, Jay P. Klarnet, Martin A. Cheever, Kenneth H. Grabstein
    Pages 429-445
  18. Back Matter
    Pages 447-459

About this book

Introduction

The study of the phenotypic and genetic features that characterize the malignant cell is a rapidly growing and changing field. Clearly new insights into the processes involved in normal and abnormal cell growth will facilitate our understanding of events relevant to cancer and cellular differentiation. Early studies on genetic fea­ tures associated with cancer focused on chromosomal abnormalities that were observable in several human malignancies. The more recent examination of onco­ genes and the proteins they encode has helped pinpoint many steps in different processes that might be involved in cancer. Immunologic studies of cancer have also developed from an imprecise series of investigations to a more detailed molecular examination of cell-surface struc­ tures that can be recognized immunologically. In the course of the development of modern tumor immunology, it has become clear that many of the antigens that can be recognized appear to be the products of genes involved in cell growth. Fur­ thermore, changes in the cell surface of malignant cells have often been found to include alteration of nonprotein constituents.

Keywords

biology cell cell growth cellular differentiation cytogenetics development genetics growth leukemia lymphocytes melanoma oncogene transplantation tumor tumorigenesis

Editors and affiliations

  • Mark I. Greene
    • 1
  • Toshiyuki Hamaoka
    • 2
  1. 1.Division of Immunology, Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of Oncogenesis, Institute for Cancer ResearchOsaka University Medical SchoolOsakaJapan

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