Oxygen Radicals in the Pathophysiology of Heart Disease

  • Pawan K. Singal

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Paul B. McCay, Edward K. Lai, Donald D. Gibson, J. Lee Poyer, Saul R. Powell, Gemma Brueggemann
    Pages 13-24
  3. D. L. Tribble, F. G. Kennedy, D. P. Jones
    Pages 25-40
  4. I. T. Mak, W. B. Weglicki
    Pages 41-53
  5. M. Gupta, K. K. Gupta, P. K. Singal
    Pages 55-70
  6. H. Fliss, M. Masika, D. W. Eley, B. Korecky
    Pages 71-90
  7. R. Ferrari, S. Curello, C. Ceconi, A. Cargnoni, E. Condorelli, A. Albertini
    Pages 145-160
  8. Alexander D. Romaschin, Donald A. G. Mickle
    Pages 177-188
  9. James M. Downey, Lynne J. Eddy, Chiaki Shirato, Patricia Molina, Miguel Molina
    Pages 189-202
  10. Roberto Bolli, Robert Roberts
    Pages 203-225
  11. C. Guarnieri, C. Muscari, A. Fraticelli, C. M. Caldarera
    Pages 271-283
  12. David V. Godin, Saleh A. Wohaieb
    Pages 303-322
  13. R. G. Schaub, C. J. Dunn, C. Orlandi
    Pages 333-342
  14. Back Matter
    Pages 343-348

About this book


Over two centuries ago, oxygen was discovered as "air vital": the component of the earth's atmosphere necessary for life. Less than five years after this discovery, it was found that oxygen was both a life-sustaining and life threatening inhalant as it plays a role in the two extremes of the animal kingdom: life and death. In the subse­ quent years, we have made major strides in understanding the role of oxygen in maintaining life and volumes of information are now available on this topic. Our knowledge of the contribution of oxygen in cellular dysfunction and cell death which for the most part had lagged behind has begun to catch up. The deleterious ef­ fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described. Recently attention has also been focused on the toxic effects of oxygen on the cardiovascular system. The major aim of the present treatise is to offer an integrated view of the pathophysiological aspects of oxygen toxicity in the heart and blood vessels coupled with a review of therapeutic approaches (hopes?) with free radical scavengers and antioxidants. Internationally known expert investigators provide a concise and critical review on the topic of their expertise which also contains data from their own research.


cardiovascular cardiovascular system cell heart lipide metabolism pathophysiology physiology research toxicity

Editors and affiliations

  • Pawan K. Singal
    • 1
    • 2
  1. 1.Division of Cardiovascular SciencesSt. Boniface General Hospital Research CenterWinnipegCanada
  2. 2.Department of Physiology, Faculty of MedicineUniversity of ManitobaWinnipegCanada

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8979-1
  • Online ISBN 978-1-4613-1743-2
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology