© 1996

Biochemistry of Signal Transduction in Myocardium

  • Jos M. J. Lamers
  • Pieter D. Verdouw

Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 17)

Table of contents

  1. Front Matter
    Pages i-1
  2. Basic Mechanisms

    1. Front Matter
      Pages 3-3
    2. Han A. A. van Heugten, Yvonne E. G. Eskildsen-Helmond, Henriette W. de Jonge, Karel Bezstarosti, Jos M. J. Lamers
      Pages 5-14
    3. Arie B. Vaandrager, Hugo R. de Jonge
      Pages 23-30
    4. Yvonne E. G. Eskildsen-Helmond, Han A. A. Van Heugten, Jos M. J. Lamers
      Pages 39-48
    5. Carine Page, Anton F. Doubell
      Pages 49-57
    6. Lucia Piacentini, Feraydoon Niroomand
      Pages 59-63
    7. Michel Pucéat, Guy Vassort
      Pages 65-72
  3. (Patho)Physiological Responses in Myocardium

    1. Front Matter
      Pages 73-73
    2. Nilanjana Maulik, Daniel T. Engelman, Masazumi Watanabe, Richard M. Engelman, Dipak K. Das
      Pages 75-86
    3. Gary L. Engelmann, Robert A. Worrell, Richard A. Duff, Patricia S. Grutkoski, Kenneth R. Chien, Richard P. Harvey
      Pages 87-91
    4. Chang-Hua Yu, Song-Yan Liu, Vincenzo Panagia
      Pages 101-105
    5. Elizabeth Vincan, Craig B. Neylon, Alexander N. Jacobsen, Elizabeth A. Woodcock
      Pages 107-110
    6. H. S. Sharma, N. Maulik, B. C. G. Gho, D. K. Das, P. D. Verdouw
      Pages 111-116
    7. Mahesh P. Gupta, Madhu Gupta, Evelyn Dizon, Radovan Zak
      Pages 117-124
    8. Ben C. Tilly, Karel Bezstarosti, Wendy E. M. Boomaars, Christopher R. Marino, Jos M. J. Lamers, Hugo R. de Jonge
      Pages 129-135

About this book


The chapters in this volume are the Proceedings of the Satellite Symposium of the XVIth World Congress of the International Society for Heart Research on `Signal Transduction in Normal and Diseased Myocardium' which was held in Rotterdam at the Faculty of Medicine & Health Sciences of the Erasmus University, June 30 and July 1, 1995.
Diverse and distinct auto-, para-, and endocrine stimuli arriving at the surface of endothelium, smooth muscle cells, cardiomyocytes and fibroblasts within the myocardium, engage cell type-specific receptors, which lead to transmission of signals across the cell plasma membrane and result in the production and activation of second messengers. The most common mechanism by which these second messengers function is via direct or indirect activation of specific protein kinases. The current challenge for scientists is to identify the specific substrates (e.g. metabolic enzymes, Ca2+-regulating proteins, transcription and mitotic factors) for the many protein kinases, to elucidate the biological significance of the cell type-specific expression heterogeneity of signalling proteins (e.g. membrane receptors, isoenzymes of protein kinase C, G-proteins) and to unravel the cross-talk interaction between the signalling systems (e.g. phospholipase C with adenylate cyclase and phospholipase C with phospholipase D). The multiplicity of receptor types, G-proteins, effector proteins, second messengers and protein kinases, their substrate proteins and the `cross-talk' interactions in the myocardium raises fundamental questions about the mechanisms that ensure the precision and timing of the myocardial responses to hormonal and pharmacological stimuli.
This book provides an up-to-date source of information for all scientists and clinicians interested in the mechanisms by which external signals are transmitted to the interior and regulation of a variety of physiological, pathological and pharmacological responses.


Angiotensin II Calcium biochemistry cardiovascular cells endothelium enzymes gene expression metabolism proteins smooth muscle tissue transcription

Editors and affiliations

  • Jos M. J. Lamers
    • 1
  • Pieter D. Verdouw
    • 2
  1. 1.Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine of Health ScienceErasmus University RotterdamRotterdamThe Netherlands
  2. 2.Department of Cardiology, Cardiovascular Research Institute COEURErasmus University RotterdamRotterdamThe Netherlands

Bibliographic information

  • Book Title Biochemistry of Signal Transduction in Myocardium
  • Editors Jos M.J. Lamers
    Pieter D. Verdouw
  • Series Title Developments in Molecular and Cellular Biochemistry
  • DOI
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-7923-4067-6
  • Softcover ISBN 978-1-4612-8544-1
  • eBook ISBN 978-1-4613-1275-8
  • Edition Number 1
  • Number of Pages VI, 274
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Biochemistry, general
  • Buy this book on publisher's site
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