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Biochemistry of Signal Transduction in Myocardium

  • Jos M. J. Lamers
  • Pieter D. Verdouw

Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 17)

Table of contents

  1. Front Matter
    Pages i-1
  2. Basic Mechanisms

    1. Front Matter
      Pages 3-3
    2. Han A. A. van Heugten, Yvonne E. G. Eskildsen-Helmond, Henriette W. de Jonge, Karel Bezstarosti, Jos M. J. Lamers
      Pages 5-14
    3. Arie B. Vaandrager, Hugo R. de Jonge
      Pages 23-30
    4. Yvonne E. G. Eskildsen-Helmond, Han A. A. Van Heugten, Jos M. J. Lamers
      Pages 39-48
    5. Carine Page, Anton F. Doubell
      Pages 49-57
    6. Lucia Piacentini, Feraydoon Niroomand
      Pages 59-63
    7. Michel Pucéat, Guy Vassort
      Pages 65-72
  3. (Patho)Physiological Responses in Myocardium

    1. Front Matter
      Pages 73-73
    2. Nilanjana Maulik, Daniel T. Engelman, Masazumi Watanabe, Richard M. Engelman, Dipak K. Das
      Pages 75-86
    3. Gary L. Engelmann, Robert A. Worrell, Richard A. Duff, Patricia S. Grutkoski, Kenneth R. Chien, Richard P. Harvey
      Pages 87-91
    4. Chang-Hua Yu, Song-Yan Liu, Vincenzo Panagia
      Pages 101-105
    5. Elizabeth Vincan, Craig B. Neylon, Alexander N. Jacobsen, Elizabeth A. Woodcock
      Pages 107-110
    6. H. S. Sharma, N. Maulik, B. C. G. Gho, D. K. Das, P. D. Verdouw
      Pages 111-116
    7. Mahesh P. Gupta, Madhu Gupta, Evelyn Dizon, Radovan Zak
      Pages 117-124
    8. Ben C. Tilly, Karel Bezstarosti, Wendy E. M. Boomaars, Christopher R. Marino, Jos M. J. Lamers, Hugo R. de Jonge
      Pages 129-135
    9. Ingrid Fleming, Johann Bauersachs, Rudi Busse
      Pages 137-145
  4. Normal and Failing Myocardium

    1. Front Matter
      Pages 147-147
    2. Elizabeth J. Kelso, Robert F. Geraghty, Barbara J. McDermott, Elisabeth R. Trimble, D. Paul Nicholls, Bernard Silke
      Pages 149-155
    3. Tzu-Hurng Cheng, Fan-Yen Lee, Jeng Wei, Cheng-I Lin
      Pages 157-162
    4. Madhu B. Anand-Srivastava
      Pages 163-170
    5. Sabine Bartel, Birgitt Stein, Thomas Eschenhagen, Ulrike Mende, Joachim Neumann, Wilhelm Schmitz et al.
      Pages 171-179
    6. Xavier J. Martin, Dylan G. Wynne, Peter E. Glennon, Anton F. M. Moorman, Kenneth R. Boheler
      Pages 181-189
    7. Deepak Kaura, Nobuakira Takeda, Rajat Sethi, Xi Wang, Makoto Nagano, Naranjan S. Dhalla
      Pages 191-196
  5. Cardiovascular Therapeutics

    1. Front Matter
      Pages 197-197
    2. Henriëtte W. de Jonge, Dick H. W. Dekkers, Jos M. J. Lamers
      Pages 199-210
    3. A. H. Jan Danser
      Pages 211-216
    4. Alessandra Bordoni, Josè A. Lopez-Jimenez, Christian Spanò, PierLuigi Biagi, David F. Horrobin, Silvana Hrelia
      Pages 217-222
    5. Carlo Guarnieri, Emanuele Giordano, Claudio Muscari, Loris Grossi, Claudio Marcello Caldarera
      Pages 223-228
    6. Barbara Huisamen, Amanda Lochner
      Pages 229-232
    7. Wim Sluiter, Wil J. A. de Vree, Anneke Pietersma, Johan F. Koster
      Pages 233-238
    8. H. A. J. Struijker-Boudier, M. W. J. Messing, H. van Essen
      Pages 239-244
    9. Ursula Ravens, Herbert M. Himmel, Michael Flüss, Kerry Davia, Sian E. Harding
      Pages 245-249
    10. Wilhelm Schmitz, Peter Boknik, Bettina Linck, Frank U. Müller
      Pages 251-258
  6. Back Matter
    Pages 269-274

About this book

Introduction

The chapters in this volume are the Proceedings of the Satellite Symposium of the XVIth World Congress of the International Society for Heart Research on `Signal Transduction in Normal and Diseased Myocardium' which was held in Rotterdam at the Faculty of Medicine & Health Sciences of the Erasmus University, June 30 and July 1, 1995.
Diverse and distinct auto-, para-, and endocrine stimuli arriving at the surface of endothelium, smooth muscle cells, cardiomyocytes and fibroblasts within the myocardium, engage cell type-specific receptors, which lead to transmission of signals across the cell plasma membrane and result in the production and activation of second messengers. The most common mechanism by which these second messengers function is via direct or indirect activation of specific protein kinases. The current challenge for scientists is to identify the specific substrates (e.g. metabolic enzymes, Ca2+-regulating proteins, transcription and mitotic factors) for the many protein kinases, to elucidate the biological significance of the cell type-specific expression heterogeneity of signalling proteins (e.g. membrane receptors, isoenzymes of protein kinase C, G-proteins) and to unravel the cross-talk interaction between the signalling systems (e.g. phospholipase C with adenylate cyclase and phospholipase C with phospholipase D). The multiplicity of receptor types, G-proteins, effector proteins, second messengers and protein kinases, their substrate proteins and the `cross-talk' interactions in the myocardium raises fundamental questions about the mechanisms that ensure the precision and timing of the myocardial responses to hormonal and pharmacological stimuli.
This book provides an up-to-date source of information for all scientists and clinicians interested in the mechanisms by which external signals are transmitted to the interior and regulation of a variety of physiological, pathological and pharmacological responses.

Keywords

Angiotensin II Calcium biochemistry cardiovascular cells endothelium enzymes gene expression metabolism proteins smooth muscle tissue transcription

Editors and affiliations

  • Jos M. J. Lamers
    • 1
  • Pieter D. Verdouw
    • 2
  1. 1.Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine of Health ScienceErasmus University RotterdamRotterdamThe Netherlands
  2. 2.Department of Cardiology, Cardiovascular Research Institute COEURErasmus University RotterdamRotterdamThe Netherlands

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