Drug Resistance

  • William N. Hait

Part of the Cancer Treatment and Research book series (CTAR, volume 87)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Membrane Transport Mechanisms

    1. Front Matter
      Pages 1-1
    2. Susan P. C. Cole, Roger G. Deeley
      Pages 39-62
  3. Resistance to Alkylating Agents

    1. Front Matter
      Pages 63-63
    2. Philip G. Penketh, Krishnamurthy Shyam, Alan C. Sartorelli
      Pages 65-81
    3. Abhijit Raha, Kenneth D. Tew
      Pages 83-122
    4. Omer N. Koç, Weldon P. Phillips Jr, Keunmyoung Lee, Lili Liu, Nasir H. Zaidi, James A. Allay et al.
      Pages 123-146
  4. Resistance to Microtubule Active Drugs

    1. Front Matter
      Pages 147-147
    2. Anna M. Casazza, Craig R. Fairchild
      Pages 149-171
  5. Resistance to Antimetabolites

    1. Front Matter
      Pages 173-173
    2. Edward Chu, Carmen J. Allegra
      Pages 175-195
    3. Elizabeth A. Rayl, Giuseppe Pizzorno
      Pages 197-223
  6. Topoisomerases

    1. Front Matter
      Pages 241-241
    2. Eric H. Rubin, Tsai-Kun Li, Pu Duann, Leroy F. Liu
      Pages 243-260
  7. Resistance to Endocrine Therapies

    1. Front Matter
      Pages 261-261
    2. Robert Clarke, Todd Skaar, Fabio Leonessa, Brenda Brankin, Mattie James, Nils Brünner et al.
      Pages 263-283
    3. Edward P. Gelmann
      Pages 285-302
  8. Resistance to Retinoids

    1. Front Matter
      Pages 303-303
    2. Josephia R. F. Muindi
      Pages 305-342
  9. Novel Mechanisms and Approaches

    1. Front Matter
      Pages 343-343
    2. Stuart G. Lutzker, Arnold J. Levine
      Pages 345-356
    3. Clay M. Anderson, Antonio C. Buzaid, Elizabeth A. Grimm
      Pages 357-380
    4. John R. Murren, Germana Rappa, Yung-Chi Cheng
      Pages 381-408
  10. Back Matter
    Pages 409-418

About this book


Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time.
In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.


DNA Drogen apoptosis breast cancer cancer chemotherapy drug drug resistance hormones immunodeficiency melanoma prostate cancer research resistance virus

Editors and affiliations

  • William N. Hait
    • 1
    • 2
    • 3
  1. 1.The Cancer Institute of New JerseyUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical SchoolPiscatawayUSA
  2. 2.Department of MedicineUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical SchoolPiscatawayUSA
  3. 3.Department of PharmacologyUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical SchoolPiscatawayUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8540-3
  • Online ISBN 978-1-4613-1267-3
  • Series Print ISSN 0927-3042
  • Buy this book on publisher's site
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