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Table of contents (19 papers)
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Role and Application of Cytokines and Growth Factors in Clinical Medicine
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Back Matter
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Future Potential of Cytokines and Growth Factors in Transfusion Medicine
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Front Matter
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Back Matter
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Back Matter
About this book
Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information.
Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume:
- Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions.
- Function, production and diagnosis &endash; laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors.
- Application in clinical medicine &endash; clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis.
- Future potential use in transfusion medicine &endash; erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.
Reviews
Australian Journal of Medical Science, 20:3 (1999)
Editors and Affiliations
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Red Cross Blood Bank Noord Nederland, The Netherlands
Cees Th. Smit Sibinga, P. C. Das
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Erasmus University, Rotterdam, The Netherlands
Bob Löwenberg
Bibliographic Information
Book Title: Cytokines and Growth Factors in Blood Transfusion
Book Subtitle: Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland
Editors: Cees Th. Smit Sibinga, P. C. Das, Bob Löwenberg
Series Title: Developments in Hematology and Immunology
DOI: https://doi.org/10.1007/978-1-4613-1137-9
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Kluwer Academic Publishers 1997
Hardcover ISBN: 978-0-7923-4787-3Published: 30 September 1997
Softcover ISBN: 978-1-4612-8435-2Published: 17 September 2011
eBook ISBN: 978-1-4613-1137-9Published: 06 December 2012
Edition Number: 1
Number of Pages: XIV, 206
Topics: Oncology, Hematology, Laboratory Medicine
Industry Sectors: Biotechnology, Health & Hospitals, Pharma