© 1988

Endothelial Cell Biology in Health and Disease

  • Nicolae Simionescu
  • Maya Simionescu

Table of contents

  1. Front Matter
    Pages i-xix
  2. Structure—Function Correlations in Endothelial Cells

    1. Front Matter
      Pages 1-1
    2. G. E. Palade
      Pages 3-22
  3. Transport Functions of Endothelial Cells

    1. Front Matter
      Pages 49-49
    2. Eugene M. Renkin
      Pages 51-68
    3. John H. Hansen-Flaschen, Alfred P. Fishman
      Pages 105-120
  4. Endothelial Cell Growth and Differentiation

    1. Front Matter
      Pages 121-121
    2. Ronald L. Heimark, Stephen M. Schwartz
      Pages 123-143
  5. Endothelial Cytoskeleton and Matrix and Their Interactions

    1. Front Matter
      Pages 145-145
    2. Werner W. Franke, Pamela Cowin, Christine Grund, Caecilia Kuhn, Hans-Peter Kapprell
      Pages 147-166
    3. Joseph A. Madri, Bruce M. Pratt, Judith Yannariello-Brown
      Pages 167-188
  6. Endothelial Cell Anticoagulant and Fibrinolytic Activities

    1. Front Matter
      Pages 189-189
    2. Scott A. Curriden, Thomas J. Podor, David J. Loskutoff
      Pages 229-252
  7. Endothelial Cell Procoagulant Activity

    1. Front Matter
      Pages 253-253
    2. Michael A. Gimbrone Jr., Michael P. Bevilacqua
      Pages 255-273
    3. David M. Stern, Dean A. Handley, Peter P. Nawroth
      Pages 275-306

About this book


Although blood capillaries were first observed through a flea-lens microscope by Malpighi in 1661,200 more years elapsed before the cellular nature of the vessel wall was conclusively demonstrated. Beginning with the middle of the 19th cen­ tury, our knowledge of the histological organization of blood vessels has steadily increased. However, the endothelium, which for a long time was considered to be just an inert barrier lining, had been barely explored until three decades ago. Since then, there has been an upsurge of interest in the fine structure and function of endothelial cells. Intense in vivo and in vitro investigations have revealed that the endothelial cell is a key element in a wide variety of normal activities and diseases. A large number of investigators and laboratories have been attracted to endothelial cell research, thus supporting the expansion of the continuously grow­ ing and diversifying field of endotheliology. The number of articles published annually on this subject has increased from a few score at the beginning of the 1970s to more than a thousand in recent years, and an increasing number of journals, books, societies, and symposia focused primarily on the vascular en­ dothelium have marked the last decade.


Vivo biochemistry biology cell cell biology cell growth developmental biology electron microscopy hypertension inflammatory response influence physiology proteins regulation tissue

Editors and affiliations

  • Nicolae Simionescu
    • 1
  • Maya Simionescu
    • 1
  1. 1.Institute of Cellular Biology and PathologyBucharestRomania

Bibliographic information

Industry Sectors
Health & Hospitals