Biocompatibility of Co-Cr-Ni Alloys

  • Hartmut F. Hildebrand
  • Maxime Champy

Part of the NATO ASI Series book series (NSSA, volume 171)

Table of contents

  1. Front Matter
    Pages i-ix
  2. The International Standards Organization Technical Committee on Surgical Implants

  3. Fundamental Aspects

  4. Tissue Response

    1. Front Matter
      Pages 81-81
    2. Surendra Singh, Harcharan Singh Ranu
      Pages 101-105
    3. Pierre Guiraldenq, Henri Mazille, Jacques Brugirard, Martine Bouvier, Henri Magloire
      Pages 107-118
    4. Jef A. Helsen
      Pages 119-132
    5. H. F. Hildebrand, P. Ostapczuk, J. F. Mercier, M. Stoeppler, B. Roumazeille, J. Decoulx
      Pages 133-153
    6. A. Garuet, M. Simonoff, B. Berdeu, Y. Llabador, F. X. Michelet, P. F. Caitucoli
      Pages 161-173
    7. Patrick Exbrayat, Marie-lise Couble, Daniel Hartmann, Henri Magloire
      Pages 175-182
    8. J. Black, D. F. Williams
      Pages 183-184
  5. Immunopathology

    1. Front Matter
      Pages 185-185
    2. Claude Benezra, Maurice J. F. Leroy
      Pages 187-192
    3. Francisque Leynadier, Francois Langlais
      Pages 193-200
    4. Hartmut F. Hildebrand, Christian Veron, Pierre Martin
      Pages 201-211
    5. L. A. J. Van Loon, P. W. Van Elsas, P. P. E. Duysters, J. D. Bos, C. L. Davidson
      Pages 213-223
    6. Karel J. J. Vreeburg, Klaas de Groot, Cees K. H. v.d. Burg, Rik. J. Scheper
      Pages 225-233
    7. C. Benezra, K. Merritt
      Pages 235-237
  6. Clinical Aspects

    1. Front Matter
      Pages 239-239
    2. Y. Andrianne, F. Burny, J. Quintin, M. Donkerwolke
      Pages 249-265
    3. M. Donazzan, M. Chanavaz, L. Duret, C. Véron, J. P. Fernandez
      Pages 267-273
    4. Eberhard Fischer-Brandies, Eckhard Dielert
      Pages 287-292
    5. D. Choudat, F. Vallentin, P. Brochard, T. Berriau, J. Proteau
      Pages 293-298
    6. B. Bloch, R. Söremark
      Pages 299-301
  7. Quality Control

    1. Front Matter
      Pages 303-303
    2. Jean-Marc Meyer
      Pages 305-320
    3. C. Gabbi, G. Melotti, E. Vita Finzi, P. Tranquilli Leali
      Pages 321-324
    4. G. Milazzo
      Pages 325-330
    5. Monique Simonoff, Bernard Berdeu, Yvan Llabador, A. Garuet, P. F. Caitucoli, F. X. Michelet
      Pages 331-340
    6. D. Muster, M. Champy, S. Szmukler, C. Baltzinger, C. Burggraf
      Pages 341-348
    7. C. Sella, J. C. Martin, J. Lecoeur, J. P. Bellier, J. P. Davidas
      Pages 349-361
    8. G. Milazzo
      Pages 363-365
  8. Conclusions and Recommendations

    1. Front Matter
      Pages 367-367
    2. Hartmut F. Hildebrand, Maxime Champy
      Pages 369-371
  9. Back Matter
    Pages 373-380

About this book


For several years now scientific and medical sLaff have recognised the risks of toxicity of certain metals contained in alloys used in Lhe manufacture of biomaterials protheses, implants, and artificial organs. A number or scientific and industrial research centres have focussed their investigations in this direction and international societies and commissions have organised meetings with specialists from complementary disciplines in attendance in attempts to guage the importance of biological risks and to determine the toxicity of certain metals, with the aim of establishing preventive measures and guidelines. In the last century great efforts have been made to reduce unwanted biological effects caused by orthopaedic implants. The problems of pain and infection were overcome and the development of modern technology has resulted in a convincing decrease in corrosion problems and mechanical failure, such that ostosynthesis and endoprosthesis have rapidly progressed beyond the level of tentative investingation.llowever, a number of problems still remain to be solved, such as the influence of the material type on the healing process and its relative speed. The increasing use of cobalt-,chromium-and nickel-containing alloys in surgical and dental implants has raised various questions concerning the biological consequences of chronic internal release of these elements in the human body. A total of 55 delegates representing 16 countries heard presentations of fundamental aspects, local and remote tissue response, immunopathology, clinical aspects, and manufacturing qual ity control issues.


Implantat biomaterial chromium control corrosion development infection manufacturing metals plants research risk surgery technology tissue

Editors and affiliations

  • Hartmut F. Hildebrand
    • 1
  • Maxime Champy
    • 2
  1. 1.Institute of Occupational MedicineLilleFrance
  2. 2.University Hospital Center of StrasbourgStrasbourgFrance

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