DNA Damage and Repair in Human Tissues

  • Betsy M. Sutherland
  • Avril D. Woodhead

Part of the Basic Life Sciences book series (BLSC, volume 53)

Table of contents

  1. Front Matter
    Pages i-ix
  2. DNA Lesion Measurement in Human Tissues

    1. Miriam C. Poirier, Ainsley Weston, Shalina Gupta-Burt, Eddie Reed
      Pages 1-11
    2. Kurt Randerath, Erika Randerath
      Pages 13-32
    3. Regina M. Santella, Xiao Yen Yang, Ling Ling Hsieh, Tie Lan Young, Xiao Qing Lu, Marina Stefanidis et al.
      Pages 33-44
    4. John C. Sutherland, Chun Zhang Chen, Ann Emrick, Haim Hacham, Denise C. Monteleone, Eldred Ribeiro et al.
      Pages 45-61
    5. Ainsley Weston, Elise D. Bowman, David K. Manchester, Curtis C. Harris
      Pages 63-81
  3. Damage and Repair in Skin

    1. Paul T. Strickland, Benjamin C. Vitasa, Magnus Bruze, Edward A. Emmett, Sheila West, Hugh R. Taylor
      Pages 83-94
    2. Kenneth H. Kraemer, Saraswathy Seetharam, Michael M. Seidman, Anders Bredberg, Douglas Brash, Haywood L. Waters et al.
      Pages 95-104
    3. Antony R Young, Christopher S Potten, Caroline A Chadwick, Gillian M Murphy, A Jeffrey Cohen
      Pages 105-116
    4. Steven E. Freeman
      Pages 117-125
    5. R. E. Davies, P. D. Forbes, F. Urbach
      Pages 127-135
    6. F. Gasparro, P. Bevilacqua, D. Goldminz, R. Edelson
      Pages 137-148
  4. Human Skin: Biochemistry and Molecular Biology

    1. Betsy M. Sutherland, Haim Hacham, Richard W. Gange, Daniel Maytum, John C. Sutherland
      Pages 149-160
    2. Herbert Hönigsmann
      Pages 161-173
    3. Hans E. Krokan, Lisbeth C. Olsen, Rein Aasland, Gunnar Volden, Guri Eggset, Bjørnar Myrnes et al.
      Pages 175-190
    4. Bjørn-Ivar Haukanes, Paul W. Doetsch, Lisbeth C. Olsen, Ikramul Huq, Hans E. Krokan, Dag E. Helland
      Pages 191-202
  5. Model Systems for Human Skin

    1. Elizabeth S. Fenjves, Joseph I. Lee, Jonathan A. Garlick, David A. Gordon, David L. Williams, Lorne B. Taichman
      Pages 215-223
    2. Lorenz Rhomberg, Vicki L. Dellarco, William H. Farland, Roger S. Cortesi
      Pages 225-232
  6. DNA Damage and Repair in Human Blood Cells

    1. Jeanette N. Hartshorn, David A. Scicchitano, Steven H. Robison
      Pages 233-249
    2. Ricardo J. Parker, Miriam C. Poirier, Freida Bostick-Bruton, Justine Vionnet, Vilhelm A. Bohr, Eddie Reed
      Pages 251-261
    3. L. L. Larcom, M. E. Smith, T. E. Morris
      Pages 263-276
    4. Bernard Strauss, Daphna Sagher, Theodore Karrison, Jeffrey Schwartz, Richard Larson, Stephanie Williams
      Pages 277-289
  7. Detection and Analysis of Human Mutations

    1. Richard J. Albertini, Janice A. Nicklas, J. Patrick O’Neill
      Pages 315-328
    2. Ronald W. Hart, Angelo Turturro, Rex A. Pegram, Ming W. Chou
      Pages 351-361
  8. Internal Organs

    1. Curtis C. Harris, Roger Reddel, Rama Modali, Teresa A. Lehman, Deborah Iman, Mary McMenamin et al.
      Pages 363-379
    2. F. Peter Guengerich, Tsutomu Shimada, Masahiko Iwasaki, Mary Ann Butler, Fred F. Kadlubar
      Pages 381-396
    3. Steven M. D’Ambrosio, Gulzar Wani, Mervyn Samuel, Ruth Gibson-D’Ambrosio, Altaf A. Wani
      Pages 397-416
    4. Altaf A. Wani, Gulzar Wani, Steven M. D’Ambrosio
      Pages 417-435
    5. R. Montesano, J. Hall, M. Hollstein, N. Mironov, C. P. Wild
      Pages 437-452
  9. Back Matter
    Pages 453-464

About this book


Physical and chemical agents in the environment damage the DNA of humans, and pose a major threat to human health today, and to the genetic integrity of human populations. Although studies on isolated DNA in vitro, on prokaryotes, on mammalian cells in culture, and on laboratory animals have provided essential background information, it is now possible to study DNA damage and repair in human tissues directly. New techniques of high sensitivity, especially those not requiring radioactive labeling have made possible quantitation of DNA damage and repair, as well as detection of residual, unrepaired DNA lesions . In recent years, several investigators have taken up the challenge of studying damage and repair responses in humans, and we have chosen that work as the special focus of this Symposium. Major advances in under­ standing damage and responses in human skin, in blood cells and in human internal organs indicate three major themes. First, DNA damage levels in human tissues depend not only on the initial exposures, but also on the capapacity of that tissue for repair of the specific lesion type. Second, repair in human tissues may differ quantitatively and qualitatively from that in human cells in culture.


DNA Laboratory Xeroderma pigmentosum blood blood cell cancer cells chromosome gene therapy genes population skin skin cancer therapy tissue

Editors and affiliations

  • Betsy M. Sutherland
    • 1
  • Avril D. Woodhead
    • 1
  1. 1.Brookhaven National LaboratoryUptonUSA

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