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Molecular Biology of Erythropoiesis

  • Joao L. Ascensao
  • Esmail D. Zanjani
  • Mehdi Tavassoli
  • Alan S. Levine
  • F. Roy MacKintosh

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 271)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Biology of Erythropoietin

    1. A. J. Erslev, J. Caro
      Pages 1-7
    2. Nicholas Dainiak, Hilde Spielvogel, Sandra Sorba, Leon Cudkowicz
      Pages 17-21
    3. Minoru Fukuda, Hiroshi Sasaki, Michiko N. Fukuda
      Pages 53-67
    4. Catherine Lacombe, Jean-Louis Da Silva, Patrick Bruneval, Jean-Loup Salzmann, Nicole Casadevall, Jean-Pierre Camilleri et al.
      Pages 69-74
    5. Shigehiko Imagawa, Mark A. Goldberg, H. Franklin Bunn
      Pages 75-85
  3. Heme Regulation and Erythropoiesis

    1. Nega Beru, Eugene Goldwasser
      Pages 87-94
    2. Blanche P. Alter, J. Matthew Schofield, Liya He, Rona S. Weinberg
      Pages 95-102
    3. J. D. Lutton, M. Laniado Schwartzman, N. G. Abraham
      Pages 115-121
    4. G. S. Marks, J. E. Mackie, S. A. McCluskey, D. S. Riddick
      Pages 123-133
  4. Globin Gene Expression

    1. Charles S. Hesdorffer, Dina Markowitz, Maureen Ward, Norma B. Lerner, Arthur Bank
      Pages 149-160
    2. Raymond A. Popp, Susan L. Bolch, Sarah G. Shinpock, Diana M. Popp
      Pages 161-176
    3. Susan P. Perrine, Paul Swerdlow, Douglas V. Faller, Gene Qin, Abraham M. Rudolph, James Reczek et al.
      Pages 177-183
  5. Erythropoiesis — Regulatory Aspects

    1. Joao L. Ascensao, Shu-Jun Liu, Jaime Caro, Eckhard Podack, Abraham Mittelmann, Esmail D. Zanjani et al.
      Pages 197-204
    2. Mitsuo Konno, Cheryl Hardy, Mehdi Tavassoli
      Pages 205-209
    3. Wei-Fan Shen, Corey Largman, Patricia Lowney, Frank M. Hack, H. Jeffrey Lawrence
      Pages 211-219
  6. Back Matter
    Pages 221-227

About this book

Introduction

This volume presents the proceedings of the Fourth Annual Symposium on the Molecular Biology of Hemopoiesis, held in Reno, Nevada, November 1 and 2, 1988. Its focus on erythropoiesis represents an attempt to cover a rapidly expanding field, which has gone from elegant studies of erythro­ poietin physiology, to molecular biology, to clinical applications and again to physiology. The rapid development has been made possible by cloning of erythropoietin gene and the availability of recombinant hormone. The regulation of heme and its derivatives has also been aided by techniques of molecular biology; there is now a concerted effort to better understand how these enzymes contribute to proliferation, differentiation and maturation of the erythron. Globin gene derrangements have been targets of recent research in an attempt to correct the defect by genetic engineering. In the chapters of this book, several groups "expressed" their views on this subject. Finally, we analyze various regulators of erythropoiesis, both in vivo and in vitro. Dr. Richard Levere was a pioneer in many studies of heme metabolism and of erythropoiesis. He has been a generous supporter of research in this field and of our past meetings. It is only. fitting that this volume should be dedicated to him.

Keywords

Hydra enzymes erythrocyte gene expression metabolism physiology regulation transcription

Editors and affiliations

  • Joao L. Ascensao
    • 1
  • Esmail D. Zanjani
    • 2
  • Mehdi Tavassoli
    • 3
  • Alan S. Levine
    • 4
  • F. Roy MacKintosh
    • 5
  1. 1.University of Connecticut Health CenterFarmingtonUSA
  2. 2.Veterans Administration Medical CenterRenoUSA
  3. 3.Veterans Administration HospitalJacksonUSA
  4. 4.National Heart, Lung, and Blood InstituteBethesdaUSA
  5. 5.University of NevadaRenoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-0623-8
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7897-9
  • Online ISBN 978-1-4613-0623-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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