© 1995

Inhibitors to Coagulation Factors

  • Louis M. Aledort
  • Leon W. Hoyer
  • Jeanne M. Lusher
  • Howard M. Reisner
  • Gilbert C. WhiteII

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 386)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Factors VIII, IX and von Willebrand factor, their molecular and antigenic structure:An overview

    1. Front Matter
      Pages 1-1
    2. Pete Lollar
      Pages 3-17
    3. Stylianos E. Antonarakis, Haig H. Kazazian, Jane Gitschier, Pierre Hutter, Philippe de Moerloose, Michael A. Morris
      Pages 19-34
    4. Dorothea Scandella, Craig Kessler, Pamela Esmon, Deborah Hurst, Suzanne Courter, Edward Gomperts et al.
      Pages 47-63
    5. Howard M. Reisner, Adella Clark, Linda Levin
      Pages 65-78
    6. P. M. Mannucci, A. B. Federici
      Pages 87-92
  3. The molecular basis of the human immune response

    1. Front Matter
      Pages 93-93
    2. David C. Benjamin
      Pages 95-108
    3. Jeff Alexander, Jörg Ruppert, Dawne M. Page, Stephen M. Hedrick, Alessandra Franco, Glenn Y. Ishioka et al.
      Pages 109-118
  4. Genetic variation and the immune response

    1. Front Matter
      Pages 119-119
    2. M. A. Robinson
      Pages 121-132
  5. Treatmnt of inhibitors

    1. Front Matter
      Pages 141-142
    2. Steven Glazer, Ulla Hedner, Jorn F. Falch
      Pages 163-174

About this book


"For the blood is the life . . . . "(Deut. 12 :23) " . . . because the blood, in its value as life, makes atonement" (Lev. 17: 11) HemoPhilia is a rare disease, severe hemophilia rarer still, yet the written history of hemophilia extends back over a millennium and a half. In the ancient Middle East, blood and life were coupled. Blood was the primary substance necessary for life, given to God in sacrifice and forbidden as a food to mortals by Levitical law. Blood was essential for rites of purification and consecration. But the flow of blood during menstruation or parturition rendered a woman unclean. The circumcision of a male child required 33 days of "blood purification" by the mother. ' Circumcision, the visible reminder of the covenant of Abraham lijith Yahweh, was required of newborn Jewish males. It "connote(d) suitability for participation in what God is doing. "2 Hence, free and uncontrolled bleeding of the male child during circumcision, during the ratification of God's covenant, would be noted with awe and concern by those of the Jewish faith. It should not be surprising that the first genetic counseling offered to families with hemophilia is found in the Babylonian Talmud (compilation of Jewish law dated to about the third century AD) and concerns the necessity for circumcision in families with what we would now call hemophilia.


Antigen autoimmune disease blood development diseases genes immune response

Editors and affiliations

  • Louis M. Aledort
    • 1
  • Leon W. Hoyer
    • 2
  • Jeanne M. Lusher
    • 3
  • Howard M. Reisner
    • 4
  • Gilbert C. WhiteII
    • 4
  1. 1.Mount Sinai Medical SchoolNew YorkUSA
  2. 2.American Red Cross Biomedical ServicesRockvilleUSA
  3. 3.Wayne State University School of Medicine and The Children’s Hospital of MichiganDetroitUSA
  4. 4.University of North Carolina at Chapel HillChapel HillUSA

Bibliographic information

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